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J Gen Virol 9 (1970), 101-103; DOI 10.1099/0022-1317-9-1-101
© 1970 Society for General Microbiology
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Reduced Interferon Response in Mice Congenitally Infected with Lymphocytic Choriomeningitis Virus

O. A. Holtermann and E. A. Havell*

The Lobund Laboratory University of Notre Dame, Notre Dame, Indiana 46556

Congenital or neonatal infection of mice with lymphocytic choriomeningitis (LCM) virus results in a life-long virus carrier state (Traub, 1936; Hotchin, 1962). In a number of mouse strains, but not in all, this persistent infection may result in a slowly progressing disease. Generally the disease does not manifest itself before the animals are several months old (Hotchin, 1965). A chronic, non-cytopathogenic infection can also be established in mouse cells in vitro. After an initial high virus yield, infected cultures continuously produce virus at a variable but restricted rate, without impairment of cell growth (Lehmann-Grube, Slenczka & Tees, 1969).

The chronic virus carrier state of mice may result in altered susceptibility to infection with other viruses, e.g. eastern equine encephalomyelitis (Wagner & Snyder, 1962), Rauscher leukaemia virus (Young & Barski, 1966), polyoma virus (Hotchin, 1962); in other instances susceptibility may not be changed, e.g. yellow fever (Volkert, Larsen & Pfau, 1964) or ectromelia (Mims & Subrahmanyan, 1966).

* Supported by U.S.P.H.S. Training Grant No. GM 01248 from the National Institute of Medical Sciences (awarding unit).

Received 27 April 1970; accepted 30 June 1970.




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Copyright © 1970 by the Society for General Microbiology.