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Synthesis of Virus Macromolecules in L-929 Cells Infected with Mayaro Virus

Department of Microbiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103

Two electrophoretically distinct protein subunits were found in Mayaro virus, a group A arbovirus. In addition, the cytoplasm of L-929 cells infected with Mayaro virus contained five new proteins, two of which were identified as virus structural proteins. All five new proteins were present by 3 hr after infection. The slower migrating virus structural protein stimulated the production of virus-neutralizing antibody.

^* Present address: Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104.

Received 5 March 1970; accepted 8 July 1970.