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Comparison of Adenovirus Types 2 and 5 Hexons by Immunological and Biochemical Techniques

National Institute for Medical Research, Mill Hill, London, N.W.7, England

W. G. Laver

John Curtin School of Medical Research Australian National University, Canberra, A.C.T., Australia

The adenovirus hexon has been shown by several workers (Wilcox, Ginsberg & Anderson, 1963; Valentine & Pereira, 1965; Norrby, 1966) to correspond to the main cross-reactive antigen shared by all adenovirus serotypes of mammalian origin. However, purified preparations of hexon induce the production of homotypic virus neutralizing antibodies (Wilcox & Ginsberg, 1963; Kasel et al. 1964, 1966; Kjellén & Pereira, 1968; Norrby, 1969) suggesting that this virus component contains type-specific as well as group-specific antigenic determinants. This suggestion is supported by results of immonodiffusion tests reported by Köhler (1965). Pettersson, Philipson & Höglund (1968) on the other hand, reported failure of purified hexon of adenovirus type 2 to induce virus neutralizing antibody.

The crystallization of hexons from human adenovirus types 2 and 5 provided us with the conditions to investigate the immunological and biochemical properties of this virus component with highly purified materials.

Received 10 August 1970; accepted 4 September 1970.