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Studies on Rubella Virus Strain Variation by Kinetic Haemagglutination-inhibition Tests

Department of Clinical Virology, St Thomas's Hospital and Medical School, London, S.E. 1

Kinetic haemagglutination-inhibition tests were used to investigate possible antigenic variation between four strains of rubella virus which had been isolated in different years and in different geographical areas. No significant differences were detected using hyperimmune rabbit sera and human sera obtained following both naturally acquired infection and vaccination with an attenuated rubella vaccine. These results suggest that major antigenic variation is unlikely to constitute a problem with rubella.

Received 15 June 1970; accepted 7 September 1970.