J Gen Virol
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Originally published as JGV in Press, 10.1099/vir.0.012302-0 on July 15, 2009 J Gen Virol 90 (2009), 2821-2828; DOI 10.1099/vir.0.012302-0

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Prion adsorption to stainless steel is promoted by nickel and molybdenum

Katarina M. Luhr1, Peter Löw1, Albert Taraboulos2, Tomas Bergman3 and Krister Kristensson1

1 Department of Neuroscience, Retzius väg 8, Karolinska Institutet, Stockholm, Sweden
2 Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
3 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Correspondence
Katarina M. Luhr
katarina.luhr{at}gmail.com

Prions are infectious agents resulting from the conversion of a normal cellular protein, PrPC, to a misfolded species, PrPSc. Iatrogenic transmission of prions is known from surgical procedures involving stainless steel materials. Here, it was shown that stainless steel containing nickel and molybdenum binds PrPSc more efficiently and transmits infection to cells in culture to a higher degree than if these elements are not present. Furthermore, both nickel and molybdenum alone adsorbed PrPSc, and nickel powder could be used to extract PrPSc from dilute solutions, thus providing a simple approach to concentration of PrPSc. The fact that nickel and molybdenum in steel alloys increased the binding affinity, and bound infectivity, of PrPSc is an important issue to consider in the manufacture of surgical instruments and abattoir tools.






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