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Production of protective gamma interferon by natural killer cells during early mouse hepatitis virus infection

Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B-1200 Bruxelles, Belgium

Correspondence
Jean-Paul Coutelier
jean-paul.coutelier{at}uclouvain.be

Gamma interferon (IFN-) plays a major role in the protection against lethal infection with mouse hepatitis virus A59. IFN- production reaches a maximum level 2 days after viral inoculation, especially in liver immune cells. Among these cells, natural killer cells are the major producers of this cytokine. Transfer experiments indicated that the protective role of IFN- is mediated through a direct effect on cells targeted by the virus rather than through indirect activation of T lymphocytes.