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Originally published as JGV in Press, 10.1099/vir.0.008599-0 on March 4, 2009 J Gen Virol 90 (2009), 1104-1108; DOI 10.1099/vir.0.008599-0

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Short Communication

Complete sequence of a duck astrovirus associated with fatal hepatitis in ducklings

Yu Fu1, Meng Pan1, Xiaoyan Wang1, Yongliang Xu1, Xiaoyu Xie1, Nick J. Knowles2, Hanchun Yang1 and Dabing Zhang1

1 Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
2 Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK

Correspondence
Hanchun Yang
yanghanchun1{at}cau.edu.cn
Dabing Zhang
zdb{at}cau.edu.cn

Duck astroviruses (DAstVs) are known to cause duck viral hepatitis; however, little is known regarding their molecular biology. Here, we report the complete sequence of a DAstV associated with a recent outbreak of fatal hepatitis in ducklings in China. Sequence analyses indicated that the genome of DAstV possessed a typical astrovirus organization and also exhibited two unique features. The polyadenylated genome comprised 7722 nt, which is the largest among astroviruses sequenced to date. The ORF2 of DAstV was not in the same reading frame as either ORF1a or ORF1b, which was distinct from all other astroviruses. Sequence comparisons and phylogenetic analyses revealed that DAstV was more closely related to turkey astrovirus (TAstV) type 2, TAstV-3 and TAstV/MN/01 (a possible new TAstV serotype) than to TAstV-1 or other astroviruses. These findings suggest that astroviruses may transmit across ducks and turkeys.

The GenBank/EMBL/DDBJ accession number of the astrovirus sequence reported in this study is FJ434664.

The primer sequences and the RT-PCR protocol used in this study are available with the online version of this paper.




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[Abstract] [Full Text] [PDF]


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