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Originally published as JGV in Press, 10.1099/vir.0.009225-0 on March 4, 2009 J Gen Virol 90 (2009), 1471-1476; DOI 10.1099/vir.0.009225-0

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Short Communication

Analysis of the complete genome sequence of epidemic keratoconjunctivitis-related human adenovirus type 8, 19, 37 and a novel serotype

Hisatoshi Kaneko1, Tomohiro Iida2, Hiroaki Ishiko3, Takeshi Ohguchi4, Toshihide Ariga4, Yoshitsugu Tagawa4, Koki Aoki4, Shigeaki Ohno4 and Tatsuo Suzutani1

1 Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima, Japan
2 Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
3 Host Defense Laboratory, Mitsubishi Chemical Medience Corporation, Tokyo, Japan
4 Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Correspondence
Hisatoshi Kaneko
h-kane{at}chive.ocn.ne.jp

We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analysed a total of 12 HAdV strains; three prototype strains and two HAdV-8, three HAdV-19 and three HAdV-37 clinical isolates from EKC patients in Japan, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99 % among strains from the same serotype, except for HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop 1 and loop 2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber may be related to ocular tropism.

The GenBank/EMBL/DDBJ accession numbers for the human adenovirus complete sequences determined in this study are AB448767–AB448778.






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