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Originally published as JGV in Press, 10.1099/vir.0.009290-0 on March 25, 2009 J Gen Virol 90 (2009), 1757-1761; DOI 10.1099/vir.0.009290-0

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Short Communication

Genetic and temporal dynamics of human immunodeficiency virus type 1 CRF07_BC in Xinjiang, China

Ruolei Xin1, Xiang He1, Hui Xing1, Feng Sun2, Mingjian Ni3, Yuanzhi Zhang3, Zhefeng Meng1, Yi Feng1, Shengya Liu1,{dagger}, Jing Wei1 and Yiming Shao1

1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China
2 Center for Disease Control and Prevention of Yili, Yining 835000, PR China
3 Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830000, PR China

Correspondence
Yiming Shao
yshao{at}bbn.cn
Xiang He
xhe{at}chinaaids.cn

To explore the temporal genetic variation of human immunodeficiency virus type 1 CRF07_BC and reconstruct its epidemic in Xinjiang, China, we studied 216 C2–V4 fragments of env genes sampled from 1996 to 2008. Phylogenetic analysis indicates that the viruses prevailing in Xinjiang form a large monophyletic cluster and may have originated from a common ancestor. The epidemic in Xinjiang was probably established around 1995 (95 % confidence interval, 1994–1996). We noted an increased diversity of CRF07_BC over time, with a rapid evolutionary rate we estimated to be 8.3x10–3 substitutions per site per year in the env gene. After 5–6 years of the epidemic (1997–2002), the transmission rate of CRF07_BC in Xinjiang slowed down, although CRF07_BC infection remained at a high prevalence.

{dagger}Present address: Medical Laboratory of Shenzhen International Travel Healthcare Center, Shenzhen 518033, PR China.

The GenBank/EMBL/DDBJ accession numbers of the sequences reported in this study are FJ875724–FJ875939.

Supplementary material is available with the online version of this paper.






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