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Originally published as JGV in Press, 10.1099/vir.0.010199-0 on May 7, 2009 J Gen Virol 90 (2009), 1806-1811; DOI 10.1099/vir.0.010199-0

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Short Communication

HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes

Koichiro Suemori1, Hiroshi Fujiwara1, Toshiki Ochi1, Taiji Ogawa1, Masao Matsuoka2, Tadashi Matsumoto3, Jean-Michel Mesnard4 and Masaki Yasukawa1

1 Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
2 Laboratory for Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan
3 Division of Hematology and Oncology, Jiaikai Imamura Hospital, Kagoshima, Japan
4 Université Montpellier 1, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS UM5236, Montpellier, France

Correspondence
Masaki Yasukawa
yasukawa{at}m.ehime-u.ac.jp

Recently, HBZ has been reported to play an important role in the proliferation of adult T-cell leukaemia (ATL) cells and might be a target of novel therapy for ATL. To develop a novel immunotherapy for ATL, we verified the feasibility of cellular immunotherapy targeting HBZ. We established an HBZ-specific and HLA-A*0201-restricted cytotoxic T lymphocyte (CTL) clone. Detailed study using this CTL clone clearly showed that HBZ is certainly an immunogenic protein recognizable by human CTLs; however, HBZ-specific CTLs could not lyse ATL cells. Failure of HBZ-specific CTLs to recognize human T-cell leukemia virus type 1 (HTLV-1)-infected cells might be due to a low level of HBZ protein expression in ATL cells and resistance of HTLV-1-infected cells to CTL-mediated cytotoxicity. Although HBZ plays an important role in the proliferation of HTLV-1-infected cells, it may also provide a novel mechanism that allows them to evade immune recognition.






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