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Published online ahead of print on 4 March 2009 as doi:10.1099/vir.0.007179-0
Journal of General Virology 2009;90:863.

A more recent version of this article appeared on April 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.007179-0
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Sequence analysis and comparison of avian Hepatitis E viruses from Australia and Europe indicate the existence of different genotypes

Ivana Bilic1, Barbara Jaskulska1, Ana Basic1, Chris John Morrow2 and Michael Hess1,3

1 Vienna University of Veterinary Medicine;
2 Bioproperties Ltd, Ringwood, Victoria, Australia

3 E-mail: michael.hess{at}vu-wien.ac.at

Avian Hepevirus infections were detected in chickens suffering from big liver and spleen disease or hepatitis-splenomegaly syndrome in Australia, USA and Europe. Available data indicate their genetic relationship with mammalian hepatitis E virus (HEV). In the present study the near complete genomic sequences of an Australian and European isolate of avian hepatitis E virus (avian HEV) are reported for the first time. Furthermore, the phylogentic relationship to other avian HEVs is determined. Sequence analyses of these isolates identified major genetic differences among avian HEVs. Most of them are located within ORF1 region, although only a few within conserved motifs of predicted domains. The non-silent mutations in ORF2 region suggest the presence of potentially different epitopes among avian HEV. Finally, the phylogenetic analysis confirmed the distant relationship to mammalian HEV and additionally suggested that the avian HEVs can be separated in three different genotypes: genotype 1 (Australia), 2 (USA) and 3 (Europe), indicating geographic distribution pattern.

Received 10 September 2008; accepted 8 December 2008.




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