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Published online ahead of print on 4 March 2009 as doi:10.1099/vir.0.007807-0
Journal of General Virology 2009;90:935.

A more recent version of this article appeared on April 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.007807-0
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Diversity of the G3 genes of human rotaviruses in isolates from Spain from 2004-2006: cross-species transmission and inter-genotype recombination generates alleles

JORGE MARTINEZ-LASO1,3, ANGELA ROMAN1, MIRIAM RODRIGUEZ1, ISABEL CERVERA1, JACQUELINE HEAD2, ICIAR RODRIGUEZ-AVIAL2 and JUAN J. PICAZO2

1 INSTITUTO SALUD CARLOS III;
2 HOSPITAL CLINICO SAN CARLOS

3 E-mail: jmlaso{at}isciii.es

Rotavirus evolves by multiple genetic mechanisms as accumulation of spontaneous point mutations and reassortment events. Other mechanisms such as cross-species transmission and inter-genotype recombination may be also involved. One of the most interesting genotypes in the accumulation of these events is G3. In this work, 6 new G3 Spanish sequences belonging to 0-2 years old patients from Madrid were analysed and compared with 160 others of the same genotype obtained from humans and other host species to establish the G3 genotype evolutionary pathways. The following results were obtained: 1) Four different lineages of the G3 genotype which have evolved in different species were described; 2) Spanish G3 rotavirus sequences are most similar to the sequences described belonging to the lineage I; 3) Several G3 genotype alleles were reassigned as other G genotypes; and 4) Inter-genotype recombination events in G3 viruses involving G1 and G2 were described. These findings strongly suggest multiple inter-species transmission events between different nom-human mammalian species and humans.

Received 9 October 2008; accepted 8 December 2008.




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