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Published online ahead of print on 4 March 2009 as doi:10.1099/vir.0.008870-0
Journal of General Virology 2009;90:1148.

A more recent version of this article appeared on May 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.008870-0
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Infectious Bursal Disease Virus Persistently Infects Bursal B Lymphoid DT40 Cells

Laura Delgui1, Dolores González and Jose F. Rodríguez

Centro Nacional de Biotecnología

1 E-mail: ldelgui{at}cnb.csic.es

Infectious bursal disease virus (IBDV), an important avian pathogen, exhibits an exquisite tropism for immature B lymphocyte cell populations. We have investigated the ability of IBDV to replicate in chicken B lymphoid DT40 cells, a tumor cell line derived from the Fabricius bursa of a chicken infected with avian leukosis virus. Our results show that IBDV persistently infects DT40 cells. The establishment of the persistent infection is associated with an extensive remodelling of the hypervariable region of the VP2 capsid polypeptide accumulating 14 amino acid changes during the first 60 days of the persistent infection. The amino acid sequence of the non-structural VP5 polypeptide, involved in virus dissemination, is not altered during the persistent infection. Results described in this report constitute the first demonstration of the ability of IBDV to establish a persistent infection in vitro.

Received 18 November 2008; accepted 6 January 2009.




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