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Published online ahead of print on 4 March 2009 as doi:10.1099/vir.0.009225-0
Journal of General Virology 2009;90:1471.

A more recent version of this article appeared on June 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.009225-0
© 2009 Society for General Microbiology
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Analysis of the complete genome sequence of epidemic keratoconjunctivitis-related human adenovirus type 8, 19, 37 and a novel serotype

Hisatoshi Kaneko1,5, Tomohiro Iida2, Hiroaki Ishiko3, Takeshi Ohguchi4, Toshihide Ariga4, Yoshitsugu Tagawa4, Koki Aoki4, Shigeaki Ohno4 and Tatsuo Suzutani1

1 Department of Microbiology, Fukushima Medical University School of Medicine;
2 Department of Ophthalmology, Fukushima Medical University School of Medicine;
3 Host Defense Laboratory, Mitsubishi Chemical Medience Corporation;
4 Department of Ophthalmology and Visual Sciences Hokkaido University Graduate School of Medicine

5 E-mail: h-kane{at}chive.ocn.ne.jp

We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analyzed a total of 12 HAdV strains; each prototype strain and 2, 3 and 3 clinical strains, isolated from EKC patients in Japan, of HAdV-8, HAdV-19 and HAdV-37, respectively, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99 % among strains from the same serotype, except HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop1 and loop2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber is related to ocular tropism.

Received 27 November 2008; accepted 10 February 2009.




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