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Published online ahead of print on 1 April 2009 as doi:10.1099/vir.0.010553-0
Journal of General Virology 2009;90:1962.

A more recent version of this article appeared on August 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.010553-0
© 2009 Society for General Microbiology
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Evaluation of smallpox vaccines using variola neutralization

Inger K. Damon1,4, Whitni B. Davidson1, Christine M. Hughes1, Victoria A. Olson1, Scott K. Smith1, Robert C. Holman1, Sharon E. Frey2, Frances Newman2, Robert B. Belshe2, Lihan Yan3 and Kevin S. Karem1

1 Centers for Disease Control and Prevention;
2 Saint Louis University School of Medicine;
3 The EMMES Corporation

4 E-mail: iad7{at}cdc.gov

The search for a 'third' generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier in acceptance is the absence of challenge models showing induction of correlates of protective immunity against Variola virus. In this light, virus neutralization provides one of few experimental methods to show specific in vivo activity of vaccines against Variola virus. Here we provide characterization of the ability of a Modified Vaccinia Ankara (MVA) vaccine to induce variola neutralizing antibodies, and we provide comparison to that elicited by standard Dryvax vaccination.

Received 23 January 2009; accepted 28 March 2009.




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