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Published online ahead of print on 15 July 2009 as doi:10.1099/vir.0.012302-0
Journal of General Virology 2009;90:2821.

A more recent version of this article appeared on November 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.012302-0
© 2009 Society for General Microbiology
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Prion adsorption to stainless steel is promoted by nickel and molybdenum

Katarina M Luhr1,3, Peter Löw1, Albert Taraboulos2, Tomas Bergman1 and Krister Kristensson1

1 Karolinska Institutet;
2 The Hebrew University-Hadassah Medical School

3 E-mail: katarina.luhr{at}ki.se

Prions are infectious agents resulting from the conversion of a normal cellular protein, PrPC, to a misfolded species, PrPSc. Iatrogenic transmission of prions is known from surgical procedures involving stainless steel materials. We show that stainless steel containing nickel and molybdenum binds PrPSc more efficiently and transmits infection to cells in culture to a higher degree than if these elements are not present. Furthermore, both nickel and molybdenum alone adsorb PrPSc, and nickel powder can be used to extract PrPSc from dilute solutions thus providing a simple approach to concentration of PrPSc. The fact that nickel and molybdenum in steel alloys increase the binding affinity, and bound infectivity, of PrPSc is an important issue to consider in the manufacture of surgical instruments and abattoir tools.

Received 31 March 2009; accepted 13 July 2009.




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