J Gen Virol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online ahead of print on 14 October 2009 as doi:10.1099/vir.0.014134-0
Journal of General Virology 2010;91:575.

A more recent version of this article appeared on February 1, 2010 J Gen Virol (2009), DOI 10.1099/vir.0.014134-0
© 2009 Society for General Microbiology
This Article
Right arrow Full Text (Papers in Press[PDF])
Right arrow All Versions of this Article:
vir.0.014134-0v1
91/2/575    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Moreno, C. R
Right arrow Articles by Pong-Wong, R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moreno, C. R
Right arrow Articles by Pong-Wong, R.
Agricola
Right arrow Articles by Moreno, C. R
Right arrow Articles by Pong-Wong, R.

Mapping of QTL affecting classical scrapie incubation time in a population comprising several generations of scrapie infected sheep

Carole R Moreno1,4, Katayoun Moazami-Goudarzi1, Stephanie Briand1, Christele Robert1, Jean Louis Weisbecker1, Pascal Laurent1, Edmond Paul Cribiu1, Christopher S Haley2, Olivier Andréoletti3, Stephen Bishop2 and Ricardo Pong-Wong2

1 INRA;
2 The Roslin Institute and R(D)SVS, University of Edinburgh;
3 INRA-ENVT

4 E-mail: moreno{at}toulouse.inra.fr

Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ-VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on the chromosome 18, and to demonstrate QTL effects in several PrP genotypes.

Received 5 June 2009; accepted 9 October 2009.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2009 by the Society for General Microbiology.