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Fig. 1. Overview of VV morphogenesis. IMV are made in a virus factory and move on microtubules (MT) to the wrapping membranes derived from the trans-Golgi network or early endosomes. Here IMV are wrapped by a double membrane to form IEV that move to the cell surface on microtubules. At the cell surface the outermost IEV membrane fuses with the plasma membrane to form CEV that induce actin tail formation to drive the virion away from the cell. CEV may also be released to form EEV.
