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Fig. 3. Evolutionary tree of all known subtypes and genotypes of HCV, including those found in high-diversity areas of genotypes 1, 2 and 4 (sub-Saharan Africa) and 3 and 6 (south-east Asia). HCV variants still fall into six distinct clades, but with far greater numbers of genetic variants corresponding to subtypes in industrialized countries. The tree was constructed by using the neighbour-joining method as implemented in the MEGA package, using Jukes–Cantor-corrected distances between partial NS5B sequences (320 bp).
