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Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds, by P.-W. Phuan, J. A. Zorn, J. Safar, K. Giles, S. B. Prusiner, F. E. Cohen and B. C. H. May

Journal of General Virology vol. 88, part 4, pp. 1392 – 1401

Supplementary Scheme S1.

Supplementary Fig. S1. Selectivity of PrP precipitation by a solid-phase matrix is influenced by the nature of the detergent used to prepare the cell lysate.

Supplementary Fig. S2. The acridine-ligated matrix fails to affinity-purify the GPI-anchored protein Thy-1.

Supplementary Table S1. Comparison of ligand bioactivity in ScN2a cells and ability to affinity-purify PrPSc.

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