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New inhibitors of prion replication that target the amyloid precursor, by M. Charvériat, M. Reboul, Q. Wang, C. Picoli, N. Lenuzza, A. Montagnac, N. Nhiri, E. Jacquet, F. Guéritte, J.-Y. Lallemand, J.-P. Deslys and F. Mouthon

Journal of General Virology vol. 90, part 5, pp. 1294 - 1301

Supplementary Fig. S1. Schematic representation of the ICSN chemical library screen, illustrating the transition from the 2960 molecules to the eight most potent compounds. [PDF] (203 kb)

Supplementary Fig. S2. Cellular viability and PrPres inhibition of Chandler-infected SN56 cells treated with serial dilutions of the compounds. [PDF] (209 kb)







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