| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Medical Research Council Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, U.K.
Transfection experiments with plasmids containing immediate early (IE) genes of herpes simplex virus type 1 (HSV-1) have previously demonstrated a role for the IE polypeptide Vmw110 (ICP0) in stimulating expression from plasmid-encoded early gene promoters. To gain further insights into the function of Vmw110 we isolated a deletion mutant specifying a truncated form of the polypeptide which had been shown to be inactive in transfection assays. This mutant, dl1403, contained a 2 kb deletion within both the TRL and IRL copies of the Vmw110 gene, and encoded a polypeptide consisting of the original N-terminal 105 amino acids followed by 56 amino acids specified by a reading frame not used by Vmw110. dl1403 was able to replicate and produce plaques on baby hamster kidney (BHK) cells but the yield of infectious virus was 20- to 100-fold lower than obtained with wild-type HSV-1. Surprisingly, comparison of polypeptide synthesis, DNA replication and DNA encapsidation in cells infected with 5 p.f.u./cell dl1403 or wild-type HSV-1 revealed no significant differences. In addition similar numbers of particles were produced in cells infected with the two viruses, resulting in stocks of dl1403 exhibiting significantly higher particle/p.f.u. ratios. The efficiency of plaquing of dl1403 was greatly reduced in Vero and human foetal lung cells compared with BHK cells, but following infection with 5 p.f.u./cell similar yields of infectious virus were obtained from all three cell lines. Marker rescue experiments verified that the reduced yield of dl1403 in BHK cells was a consequence of the deletion within the Vmw110 gene. The results suggest that the effect of this deletion is manifest primarily at low multiplicities of infection and can be largely overcome by increasing the virus dose.
Keywords: HSV-1, immediate early polypeptide Vmw110, deletion mutant
Received 22 May 1986;
accepted 7 August 1986.
This article has been cited by other articles:
|
|
 |
|
  M. J. Wagner and J. R. Smiley Herpes Simplex Virus Requires VP11/12 To Induce Phosphorylation of the Activation Loop Tyrosine (Y394) of the Src Family Kinase Lck in T Lymphocytes J. Virol., December 1, 2009; 83(23): 12452 - 12461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kyratsous, M. S. Walters, C. A. Panagiotidis, and S. J. Silverstein Complementation of a Herpes Simplex Virus ICP0 Null Mutant by Varicella-Zoster Virus ORF61p J. Virol., October 15, 2009; 83(20): 10637 - 10643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Hancock, K. L. Mossman, and J. R. Smiley Cell Fusion-Induced Activation of Interferon-Stimulated Genes Is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed between Permissive and Restrictive Cells J. Virol., September 1, 2009; 83(17): 8976 - 8979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nystrom, R. Norden, I. Muylaert, P. Elias, G. Larson, and S. Olofsson Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes Glycobiology, August 1, 2009; 19(8): 847 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Frey, C. M. I. Ahmed, R. Dabelic, L. D. Jager, E. N. Noon-Song, S. M. Haider, H. M. Johnson, and N. J. Bigley HSV-1-Induced SOCS-1 Expression in Keratinocytes: Use of a SOCS-1 Antagonist to Block a Novel Mechanism of Viral Immune Evasion J. Immunol., July 15, 2009; 183(2): 1253 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Negorev, O. V. Vladimirova, and G. G. Maul Differential Functions of Interferon-Upregulated Sp100 Isoforms: Herpes Simplex Virus Type 1 Promoter-Based Immediate-Early Gene Suppression and PML Protection from ICP0-Mediated Degradation J. Virol., May 15, 2009; 83(10): 5168 - 5180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kyratsous and S. J. Silverstein Components of Nuclear Domain 10 Bodies Regulate Varicella-Zoster Virus Replication J. Virol., May 1, 2009; 83(9): 4262 - 4274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y.-Y. Liu, C.-H. Wang, W.-K. Hsiao, H.-R. Lo, C. P. Wu, and Y. C. Chao RING and Coiled-Coil Domains of Baculovirus IE2 Are Critical in Strong Activation of the Cytomegalovirus Major Immediate-Early Promoter in Mammalian Cells J. Virol., April 15, 2009; 83(8): 3604 - 3616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gu and B. Roizman The Two Functions of Herpes Simplex Virus 1 ICP0, Inhibition of Silencing by the CoREST/REST/HDAC Complex and Degradation of PML, Are Executed in Tandem J. Virol., January 1, 2009; 83(1): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Kyratsous and S. J. Silverstein The co-chaperone BAG3 regulates Herpes Simplex Virus replication PNAS, December 30, 2008; 105(52): 20912 - 20917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Cliffe and D. M. Knipe Herpes Simplex Virus ICP0 Promotes both Histone Removal and Acetylation on Viral DNA during Lytic Infection J. Virol., December 15, 2008; 82(24): 12030 - 12038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston and M. J. Nicholl Induction of Cellular Stress Overcomes the Requirement of Herpes Simplex Virus Type 1 for Immediate-Early Protein ICP0 and Reactivates Expression from Quiescent Viral Genomes J. Virol., December 1, 2008; 82(23): 11775 - 11783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell, R. Everett, J. Hilliard, P. Schaffer, A. Orr, and D. Davido Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner J. Virol., November 1, 2008; 82(21): 10647 - 10656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. McMahon and D. Walsh Efficient Quiescent Infection of Normal Human Diploid Fibroblasts with Wild-Type Herpes Simplex Virus Type 1 J. Virol., October 15, 2008; 82(20): 10218 - 10230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, D. F. Young, R. E. Randall, and A. Orr STAT-1- and IRF-3-Dependent Pathways Are Not Essential for Repression of ICP0-Null Mutant Herpes Simplex Virus Type 1 in Human Fibroblasts J. Virol., September 1, 2008; 82(17): 8871 - 8881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Ling, J. Tan, J. Sewatanon, and R. Peng Murine Gammaherpesvirus 68 Open Reading Frame 75c Tegument Protein Induces the Degradation of PML and Is Essential for Production of Infectious Virus J. Virol., August 15, 2008; 82(16): 8000 - 8012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, C. Parada, P. Gripon, H. Sirma, and A. Orr Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100 J. Virol., March 15, 2008; 82(6): 2661 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Coleman, V. Connor, Z. S. C. Cheng, F. Grey, C. M. Preston, and S. Efstathiou Histone modifications associated with herpes simplex virus type 1 genomes during quiescence and following ICP0-mediated de-repression J. Gen. Virol., January 1, 2008; 89(1): 68 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Terry-Allison, C. A. Smith, and N. A. DeLuca Relaxed Repression of Herpes Simplex Virus Type 1 Genomes in Murine Trigeminal Neurons J. Virol., November 15, 2007; 81(22): 12394 - 12405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0 J. Virol., November 1, 2007; 81(21): 11781 - 11789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Morency, M. Sabra, F. Catez, P. Texier, and P. Lomonte A novel cell response triggered by interphase centromere structural instability J. Cell Biol., June 21, 2007; 177(5): 757 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kummer, N. M. Turza, P. Muhl-Zurbes, M. Lechmann, C. Boutell, R. S. Coffin, R. D. Everett, A. Steinkasserer, and A. T. Prechtel Herpes Simplex Virus Type 1 Induces CD83 Degradation in Mature Dendritic Cells with Immediate-Early Kinetics via the Cellular Proteasome J. Virol., June 15, 2007; 81(12): 6326 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Thompson and N. M. Sawtell Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo J. Virol., November 15, 2006; 80(22): 10919 - 10930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hargett, S. Rice, and S. L. Bachenheimer Herpes Simplex Virus Type 1 ICP27-Dependent Activation of NF-{kappa}B J. Virol., November 1, 2006; 80(21): 10565 - 10578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, S. Rechter, P. Papior, N. Tavalai, T. Stamminger, and A. Orr PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0. J. Virol., August 1, 2006; 80(16): 7995 - 8005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Bringhurst and P. A. Schaffer Cellular Stress Rather than Stage of the Cell Cycle Enhances the Replication and Plating Efficiencies of Herpes Simplex Virus Type 1 ICP0- Viruses J. Virol., May 1, 2006; 80(9): 4528 - 4537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Melchjorsen, J. Siren, I. Julkunen, S. R. Paludan, and S. Matikainen Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-{kappa}B and IRF-3. J. Gen. Virol., May 1, 2006; 87(Pt 5): 1099 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Walsh and I. Mohr Assembly of an active translation initiation factor complex by a viral protein. Genes & Dev., February 15, 2006; 20(4): 461 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Sobol and K. L. Mossman ICP0 Prevents RNase L-Independent rRNA Cleavage in Herpes Simplex Virus Type 1-Infected Cells J. Virol., January 1, 2006; 80(1): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Naito, K. R. Mott, N. Osorio, L. Jin, and G.-C. Perng Herpes simplex virus type 1 immediate-early protein ICP0 diffuses out of infected rabbit corneas J. Gen. Virol., November 1, 2005; 86(11): 2979 - 2988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell, M. Canning, A. Orr, and R. D. Everett Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7 J. Virol., October 1, 2005; 79(19): 12342 - 12354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Elliott, W. Hafezi, A. Whiteley, and E. Bernard Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0 J. Virol., August 1, 2005; 79(15): 9735 - 9745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Geiser, Y. Zhang, and C. Jones Analysis of a bovine herpesvirus 1 recombinant virus that does not express the bICP0 protein J. Gen. Virol., July 1, 2005; 86(7): 1987 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett and J. Murray ND10 Components Relocate to Sites Associated with Herpes Simplex Virus Type 1 Nucleoprotein Complexes during Virus Infection J. Virol., April 15, 2005; 79(8): 5078 - 5089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Davido, W. F. von Zagorski, W. S. Lane, and P. A. Schaffer Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function J. Virol., January 15, 2005; 79(2): 1232 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston and M. J. Nicholl Human Cytomegalovirus Tegument Protein pp71 Directs Long-Term Gene Expression from Quiescent Herpes Simplex Virus Genomes J. Virol., January 1, 2005; 79(1): 525 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Malmgaard, J. Melchjorsen, A. G. Bowie, S. C. Mogensen, and S. R. Paludan Viral Activation of Macrophages through TLR-Dependent and -Independent Pathways J. Immunol., December 1, 2004; 173(11): 6890 - 6898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Does Not Protect Cyclins D1 and D3 from Degradation during Infection J. Virol., September 15, 2004; 78(18): 9599 - 9604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barreca and P. O'Hare Suppression of Herpes Simplex Virus 1 in MDBK Cells via the Interferon Pathway J. Virol., August 15, 2004; 78(16): 8641 - 8653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell and R. D. Everett Herpes Simplex Virus Type 1 Infection Induces the Stabilization of p53 in a USP7- and ATM-Independent Manner J. Virol., August 1, 2004; 78(15): 8068 - 8077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lomonte, J. Thomas, P. Texier, C. Caron, S. Khochbin, and A. L. Epstein Functional Interaction between Class II Histone Deacetylases and ICP0 of Herpes Simplex Virus Type 1 J. Virol., July 1, 2004; 78(13): 6744 - 6757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Augustinova, D. Hoeller, and F. Yao The Dominant-Negative Herpes Simplex Virus Type 1 (HSV-1) Recombinant CJ83193 Can Serve as an Effective Vaccine against Wild-Type HSV-1 Infection in Mice J. Virol., June 1, 2004; 78(11): 5756 - 5765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Mogensen, J. Melchjorsen, L. Malmgaard, A. Casola, and S. R. Paludan Suppression of Proinflammatory Cytokine Expression by Herpes Simplex Virus Type 1 J. Virol., June 1, 2004; 78(11): 5883 - 5890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Walsh and I. Mohr Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells Genes & Dev., March 15, 2004; 18(6): 660 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagglund and B. Roizman Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 J. Virol., March 1, 2004; 78(5): 2169 - 2178. [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, C. Boutell, and A. Orr Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0 J. Virol., February 15, 2004; 78(4): 1763 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, G. Sourvinos, C. Leiper, J. B. Clements, and A. Orr Formation of Nuclear Foci of the Herpes Simplex Virus Type 1 Regulatory Protein ICP4 at Early Times of Infection: Localization, Dynamics, Recruitment of ICP27, and Evidence for the De Novo Induction of ND10-Like Complexes J. Virol., February 15, 2004; 78(4): 1903 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fraefel, A. G. Bittermann, H. Bueler, I. Heid, T. Bachi, and M. Ackermann Spatial and Temporal Organization of Adeno-Associated Virus DNA Replication in Live Cells J. Virol., January 1, 2004; 78(1): 389 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagglund and B. Roizman Herpes Simplex Virus 1 Mutant in Which the ICP0 HUL-1 E3 Ubiquitin Ligase Site Is Disrupted Stabilizes cdc34 but Degrades D-Type Cyclins and Exhibits Diminished Neurotoxicity J. Virol., December 15, 2003; 77(24): 13194 - 13202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. W. Poon, Y. Liang, and B. Roizman Herpes Simplex Virus 1 Gene Expression Is Accelerated by Inhibitors of Histone Deacetylases in Rabbit Skin Cells Infected with a Mutant Carrying a cDNA Copy of the Infected-Cell Protein No. 0 J. Virol., December 1, 2003; 77(23): 12671 - 12678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Thompson, M. T. Shieh, and N. M. Sawtell Analysis of Herpes Simplex Virus ICP0 Promoter Function in Sensory Neurons during Acute Infection, Establishment of Latency, and Reactivation In Vivo J. Virol., November 15, 2003; 77(22): 12319 - 12330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Sandri-Goldin Replication of the herpes simplex virus genome: Does it really go around in circles? PNAS, June 24, 2003; 100(13): 7428 - 7429. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Jackson and N. A. DeLuca Relationship of herpes simplex virus genome configuration to productive and persistent infections PNAS, June 24, 2003; 100(13): 7871 - 7876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Tang, L. Li, A. M. Ishov, V. Revol, A. L. Epstein, and G. G. Maul Determination of Minimum Herpes Simplex Virus Type 1 Components Necessary To Localize Transcriptionally Active DNA to ND10 J. Virol., May 15, 2003; 77(10): 5821 - 5828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Koffa, J. Kean, G. Zachos, S. A. Rice, and J. B. Clements CK2 Protein Kinase Is Stimulated and Redistributed by Functional Herpes Simplex Virus ICP27 Protein J. Virol., April 1, 2003; 77(7): 4315 - 4325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, G. Sourvinos, and A. Orr Recruitment of Herpes Simplex Virus Type 1 Transcriptional Regulatory Protein ICP4 into Foci Juxtaposed to ND10 in Live, Infected Cells J. Virol., March 15, 2003; 77(6): 3680 - 3689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bailey and P. O'Hare Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease J. Gen. Virol., December 1, 2002; 83(12): 2951 - 2964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Marshall, K. V. Rowley, A. Rinaldi, I. P. Nicholson, A. M. Ishov, G. G. Maul, and C. M. Preston Activity and intracellular localization of the human cytomegalovirus protein pp71 J. Gen. Virol., June 1, 2002; 83(7): 1601 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhou and D. M. Knipe Association of Herpes Simplex Virus Type 1 ICP8 and ICP27 Proteins with Cellular RNA Polymerase II Holoenzyme J. Virol., May 13, 2002; 76(12): 5893 - 5904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Chen, L. Y. Lee, D. A. Garber, P. A. Schaffer, D. M. Knipe, and D. M. Coen Neither LAT nor Open Reading Frame P Mutations Increase Expression of Spliced or Intron-Containing ICP0 Transcripts in Mouse Ganglia Latently Infected with Herpes Simplex Virus J. Virol., April 16, 2002; 76(10): 4764 - 4772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Melchjorsen, F. S. Pedersen, S. C. Mogensen, and S. R. Paludan Herpes Simplex Virus Selectively Induces Expression of the CC Chemokine RANTES/CCL5 in Macrophages through a Mechanism Dependent on PKR and ICP0 J. Virol., February 22, 2002; 76(6): 2780 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Davido, D. A. Leib, and P. A. Schaffer The Cyclin-Dependent Kinase Inhibitor Roscovitine Inhibits the Transactivating Activity and Alters the Posttranslational Modification of Herpes Simplex Virus Type 1 ICP0 J. Virol., February 1, 2002; 76(3): 1077 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagglund, C. Van Sant, P. Lopez, and B. Roizman Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes PNAS, January 22, 2002; 99(2): 631 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Paludan Requirements for the Induction of Interleukin-6 by Herpes Simplex Virus-Infected Leukocytes J. Virol., September 1, 2001; 75(17): 8008 - 8015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Van Sant, R. Hagglund, P. Lopez, and B. Roizman The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity PNAS, July 5, 2001; (2001) 161283098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-L. Hsu and R. D. Everett Human Neuron-Committed Teratocarcinoma NT2 Cell Line Has Abnormal ND10 Structures and Is Poorly Infected by Herpes Simplex Virus Type 1 J. Virol., April 15, 2001; 75(8): 3819 - 3831. [Abstract] [Full Text]
|
|
|
|
|
|
P. Lopez, C. Van Sant, and B. Roizman Requirements for the Nuclear-Cytoplasmic Translocation of Infected-Cell Protein 0 of Herpes Simplex Virus 1 J. Virol., April 15, 2001; 75(8): 3832 - 3840. [Abstract] [Full Text]
|
|
|
|
|
|
W. E. Hobbs, D. E. Brough, I. Kovesdi, and N. A. DeLuca Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival J. Virol., April 1, 2001; 75(7): 3391 - 3403. [Abstract] [Full Text]
|
|
|
|
|
|
C. Van Sant, P. Lopez, S. J. Advani, and B. Roizman Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0 J. Virol., February 15, 2001; 75(4): 1888 - 1898. [Abstract] [Full Text]
|
|
|
|
|
|
P. Bell, P. M. Lieberman, and G. G. Maul Lytic but Not Latent Replication of Epstein-Barr Virus Is Associated with PML and Induces Sequential Release of Nuclear Domain 10 Proteins J. Virol., December 15, 2000; 74(24): 11800 - 11810. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Everett ICP0 Induces the Accumulation of Colocalizing Conjugated Ubiquitin J. Virol., November 1, 2000; 74(21): 9994 - 10005. [Abstract] [Full Text]
|
|
|
|
|
|
J. Parkinson and R. D. Everett Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Affect Cellular Structures and Proteins J. Virol., November 1, 2000; 74(21): 10006 - 10017. [Abstract] [Full Text]
|
|
|
|
|
|
X.-p. Chen, J. Li, M. Mata, J. Goss, D. Wolfe, J. C. Glorioso, and D. J. Fink Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture J. Virol., November 1, 2000; 74(21): 10132 - 10141. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Tang, P. Bell, P. Tegtmeyer, and G. G. Maul Replication but Not Transcription of Simian Virus 40 DNA Is Dependent on Nuclear Domain 10 J. Virol., October 15, 2000; 74(20): 9694 - 9700. [Abstract] [Full Text]
|
|
|
|
|
|
P. Cheung, K. S. Ellison, R. Verity, and J. R. Smiley Herpes Simplex Virus ICP27 Induces Cytoplasmic Accumulation of Unspliced Polyadenylated alpha -Globin Pre-mRNA in Infected HeLa Cells J. Virol., March 15, 2000; 74(6): 2913 - 2919. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Mossman, H. A. Saffran, and J. R. Smiley Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon J. Virol., February 15, 2000; 74(4): 2052 - 2056. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. R. Devireddy and C. J. Jones Olf-1, a Neuron-specific Transcription Factor, Can Activate the Herpes Simplex Virus Type 1-Infected Cell Protein 0 Promoter J. Biol. Chem., January 7, 2000; 275(1): 77 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston Repression of viral transcription during herpes simplex virus latency J. Gen. Virol., January 1, 2000; 81(1): 1 - 19. [Full Text]
|
|
|
|
|
|
R. Lu and V. Misra Potential Role for Luman, the Cellular Homologue of Herpes Simplex Virus VP16 (alpha Gene trans-Inducing Factor), in Herpesvirus Latency J. Virol., January 1, 2000; 74(2): 934 - 943. [Abstract] [Full Text]
|
|
|
|
|
|
K. R. Marshall, R. H. Lachmann, S. Efstathiou, A. Rinaldi, and C. M. Preston Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression J. Virol., January 1, 2000; 74(2): 956 - 964. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Mossman and J. R. Smiley Truncation of the C-Terminal Acidic Transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0 J. Virol., December 1, 1999; 73(12): 9726 - 9733. [Abstract] [Full Text]
|
|
|
|
|
|
P. Lomonte and R. D. Everett Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Inhibits Progression of Cells through Mitosis and from G1 into S Phase of the Cell Cycle J. Virol., November 1, 1999; 73(11): 9456 - 9467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Thomas, C. E. Lilley, D. S. Latchman, and R. S. Coffin Equine Herpesvirus 1 Gene 12 Can Substitute for vmw65 in the Growth of Herpes Simplex Virus (HSV) Type 1, Allowing the Generation of Optimized Cell Lines for the Propagation of HSV Vectors with Multiple Immediate-Early Gene Defects J. Virol., September 1, 1999; 73(9): 7399 - 7409. [Abstract] [Full Text]
|
|
|
|
|
|
S. K. Thomas, G. Gough, D. S. Latchman, R. S. , and Coffin Herpes Simplex Virus Latency-Associated Transcript Encodes a Protein Which Greatly Enhances Virus Growth, Can Compensate for Deficiencies in Immediate-Early Gene Expression, and Is Likely To Function during Reactivation from Virus Latency J. Virol., August 1, 1999; 73(8): 6618 - 6625. [Abstract] [Full Text]
|
|
|
|
|
|
C. Van Sant, Y. Kawaguchi, and B. Roizman A single amino acid substitution in the cyclin D binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate PNAS, July 6, 1999; 96(14): 8184 - 8189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bruni, B. Fineschi, W. O. Ogle, and B. Roizman A Novel Cellular Protein, p60, Interacting with both Herpes Simplex Virus 1 Regulatory Proteins ICP22 and ICP0 Is Modified in a Cell-Type-Specific Manner and Is Recruited to the Nucleus after Infection J. Virol., May 1, 1999; 73(5): 3810 - 3817. [Abstract] [Full Text]
|
|
|
|
|
|
R. Lachmann, M Sadarangani, H. Atkinson, and S Efstathiou An analysis of herpes simplex virus gene expression during latency establishment and reactivation J. Gen. Virol., May 1, 1999; 80(5): 1271 - 1282. [Abstract]
|
|
|
|
|
|
P. Lawinger, L. Rastelli, Z. Zhao, and S. Majumder Lack of Enhancer Function in Mammals Is Unique to Oocytes and Fertilized Eggs J. Biol. Chem., March 19, 1999; 274(12): 8002 - 8011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zachos, B. Clements, and J. Conner Herpes Simplex Virus Type 1 Infection Stimulates p38/c-Jun N-terminal Mitogen-activated Protein Kinase Pathways and Activates Transcription Factor AP-1 J. Biol. Chem., February 19, 1999; 274(8): 5097 - 5103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Leib, T. E. Harrison, K. M. Laslo, M. A. Machalek, N. J. Moorman, and H. W. Virgin Interferons Regulate the Phenotype of Wild-type and Mutant Herpes Simplex Viruses In Vivo J. Exp. Med., February 15, 1999; 189(4): 663 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, M. Meredith, and A. Orr The Ability of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 To Bind to a Ubiquitin-Specific Protease Contributes to Its Roles in the Activation of Gene Expression and Stimulation of Virus Replication J. Virol., January 1, 1999; 73(1): 417 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Parkinson, S. P. Lees-Miller, and R. D. Everett Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase J. Virol., January 1, 1999; 73(1): 650 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Lium, C. A. Panagiotidis, X. Wen, and S. J. Silverstein The NH2 Terminus of the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Contains a Promoter-Specific Transcription Activation Domain J. Virol., October 1, 1998; 72(10): 7785 - 7795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, P. Freemont, H. Saitoh, M. Dasso, A. Orr, M. Kathoria, and J. Parkinson The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms J. Virol., August 1, 1998; 72(8): 6581 - 6591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ziemann, T. C. Mettenleiter, and W. Fuchs Infectious Laryngotracheitis Herpesvirus Expresses a Related Pair of Unique Nuclear Proteins Which Are Encoded by Split Genes Located at the Right End of the UL Genome Region J. Virol., August 1, 1998; 72(8): 6867 - 6874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Lamond and W. C. Earnshaw Structure and Function in the Nucleus Science, April 24, 1998; 280(5363): 547 - 553. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Samaniego, L. Neiderhiser, and N. A. DeLuca Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins J. Virol., April 1, 1998; 72(4): 3307 - 3320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D O'Rourke, G Elliott, M Papworth, R Everett, and P O'Hare Examination of determinants for intranuclear localization and transactivation within the RING finger of herpes simplex virus type 1 IE110k protein J. Gen. Virol., March 1, 1998; 79(3): 537 - 548. [Abstract]
|
|
|
|
|
|
J. Arthur, R Everett, I Brierley, and S Efstathiou Disruption of the 5' and 3' splice sites flanking the major latency- associated transcripts of herpes simplex virus type 1: evidence for alternate splicing in lytic and latent infections J. Gen. Virol., January 1, 1998; 79(1): 107 - 116. [Abstract]
|
|
|
|
|
|
C. Preston, A Rinaldi, and M. Nicholl Herpes simplex virus type 1 immediate early gene expression is stimulated by inhibition of protein synthesis J. Gen. Virol., January 1, 1998; 79(1): 117 - 124. [Abstract]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
