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MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.
We have determined the DNA sequence of the long unique region (UL) in the genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained 107943 residues and had a base composition of 66.9% G+C. Together with our previous work, this completes the sequence of HSV-1 DNA, giving a total genome length of 152260 residues of base composition 68.3% G+C. Genes in the UL region were located by the use of published mapping analyses, transcript structures and sequence data, and by examination of DNA sequence characteristics. Fifty-six genes were identified, accounting for most of the sequence. Some 28 of these are at present of unknown function. The gene layout for UL was found to be very similar to that for the corresponding part of the genome of varicella-zoster virus, the only other completely sequenced alphaherpesvirus, and the amino acid sequences of equivalent proteins showed a range of similarities. In the whole genome of HSV-1 we now recognize 72 genes which encode 70 distinct proteins.
Keywords: DNA sequence, HSV-1, gene organization
Present address: Department of Molecular Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, U.K.
Present address: Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, U.K.
Present address: Plant Breeding Institute, Maris Lane, Trumpington, Cambridge CB2 2LQ, U.K.
Received 22 February 1988;
accepted 11 April 1988.
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M. Hutoran, A. Ronen, A. Perelberg, M. Ilouze, A. Dishon, I. Bejerano, N. Chen, and M. Kotler Description of an as Yet Unclassified DNA Virus from Diseased Cyprinus carpio Species J. Virol., February 15, 2005; 79(4): 1983 - 1991. [Abstract] [Full Text] [PDF]
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 K. S. Trego, Y. Zhu, and D. S. Parris The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA Nucleic Acids Res., January 26, 2005; 33(2): 536 - 545. [Abstract] [Full Text] [PDF]
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W. Fuchs, D. Wiesner, J. Veits, J. P. Teifke, and T. C. Mettenleiter In Vitro and In Vivo Relevance of Infectious Laryngotracheitis Virus gJ Proteins That Are Expressed from Spliced and Nonspliced mRNAs J. Virol., January 15, 2005; 79(2): 705 - 716. [Abstract] [Full Text] [PDF]
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J. K. Thurlow, F. J. Rixon, M. Murphy, P. Targett-Adams, M. Hughes, and V. G. Preston The Herpes Simplex Virus Type 1 DNA Packaging Protein UL17 Is a Virion Protein That Is Present in Both the Capsid and the Tegument Compartments J. Virol., January 1, 2005; 79(1): 150 - 158. [Abstract] [Full Text] [PDF]
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C. M. Preston and M. J. Nicholl Human Cytomegalovirus Tegument Protein pp71 Directs Long-Term Gene Expression from Quiescent Herpes Simplex Virus Genomes J. Virol., January 1, 2005; 79(1): 525 - 535. [Abstract] [Full Text] [PDF]
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I. M. Porter and N. D. Stow Replication, recombination and packaging of amplicon DNA in cells infected with the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 J. Gen. Virol., December 1, 2004; 85(12): 3501 - 3510. [Abstract] [Full Text] [PDF]
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W. Fuchs, B. G. Klupp, H. Granzow, and T. C. Mettenleiter Essential Function of the Pseudorabies Virus UL36 Gene Product Is Independent of Its Interaction with the UL37 Protein J. Virol., November 1, 2004; 78(21): 11879 - 11889. [Abstract] [Full Text] [PDF]
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P. Norberg, T. Bergstrom, E. Rekabdar, M. Lindh, and J.-A. Liljeqvist Phylogenetic Analysis of Clinical Herpes Simplex Virus Type 1 Isolates Identified Three Genetic Groups and Recombinant Viruses J. Virol., October 1, 2004; 78(19): 10755 - 10764. [Abstract] [Full Text] [PDF]
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P. E. Boehmer RNA binding and R-loop formation by the herpes simplex virus type-1 single-stranded DNA-binding protein (ICP8) Nucleic Acids Res., August 25, 2004; 32(15): 4576 - 4584. [Abstract] [Full Text] [PDF]
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E. Avitabile, G. Lombardi, T. Gianni, M. Capri, and G. Campadelli-Fiume Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression J. Virol., August 1, 2004; 78(15): 8015 - 8025. [Abstract] [Full Text] [PDF]
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H. Augustinova, D. Hoeller, and F. Yao The Dominant-Negative Herpes Simplex Virus Type 1 (HSV-1) Recombinant CJ83193 Can Serve as an Effective Vaccine against Wild-Type HSV-1 Infection in Mice J. Virol., June 1, 2004; 78(11): 5756 - 5765. [Abstract] [Full Text] [PDF]
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T. J. Taylor and D. M. Knipe Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteins with ICP8 J. Virol., June 1, 2004; 78(11): 5856 - 5866. [Abstract] [Full Text] [PDF]
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R. Klopfleisch, J. P. Teifke, W. Fuchs, M. Kopp, B. G. Klupp, and T. C. Mettenleiter Influence of Tegument Proteins of Pseudorabies Virus on Neuroinvasion and Transneuronal Spread in the Nervous System of Adult Mice after Intranasal Inoculation J. Virol., March 15, 2004; 78(6): 2956 - 2966. [Abstract] [Full Text] [PDF]
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I. M. Porter and N. D. Stow Virus particles produced by the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 contain abnormal genomes J. Gen. Virol., March 1, 2004; 85(3): 583 - 591. [Abstract] [Full Text] [PDF]
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R. Hagglund and B. Roizman Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 J. Virol., March 1, 2004; 78(5): 2169 - 2178. [Full Text] [PDF]
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Y. Osorio, J. Cohen, and H. Ghiasi Improved Protection from Primary Ocular HSV-1 Infection and Establishment of Latency Using Multigenic DNA Vaccines Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 506 - 514. [Abstract] [Full Text] [PDF]
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H. Granzow, B. G. Klupp, and T. C. Mettenleiter The Pseudorabies Virus US3 Protein Is a Component of Primary and of Mature Virions J. Virol., February 1, 2004; 78(3): 1314 - 1323. [Abstract] [Full Text] [PDF]
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H. Browne, S. Bell, and T. Minson Analysis of the Requirement for Glycoprotein M in Herpes Simplex Virus Type 1 Morphogenesis J. Virol., January 15, 2004; 78(2): 1039 - 1041. [Abstract] [Full Text] [PDF]
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C. M. Sanfilippo, F. N. W. Chirimuuta, and J. A. Blaho Herpes Simplex Virus Type 1 Immediate-Early Gene Expression Is Required for the Induction of Apoptosis in Human Epithelial HEp-2 Cells J. Virol., January 1, 2004; 78(1): 224 - 239. [Abstract] [Full Text] [PDF]
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B. G. Klupp, C. J. Hengartner, T. C. Mettenleiter, and L. W. Enquist Complete, Annotated Sequence of the Pseudorabies Virus Genome J. Virol., January 1, 2004; 78(1): 424 - 440. [Abstract] [Full Text] [PDF]
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B. G. Klupp, H. Granzow, W. Fuchs, E. Mundt, and T. C. Mettenleiter Pseudorabies Virus UL3 Gene Codes for a Nuclear Protein Which Is Dispensable for Viral Replication J. Virol., January 1, 2004; 78(1): 464 - 472. [Abstract] [Full Text] [PDF]
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J. Veits, D. Luschow, K. Kindermann, O. Werner, J. P. Teifke, T. C. Mettenleiter, and W. Fuchs Deletion of the non-essential UL0 gene of infectious laryngotracheitis (ILT) virus leads to attenuation in chickens, and UL0 mutants expressing influenza virus haemagglutinin (H7) protect against ILT and fowl plague J. Gen. Virol., December 1, 2003; 84(12): 3343 - 3352. [Abstract] [Full Text] [PDF]
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W. Fuchs, H. Granzow, and T. C. Mettenleiter A Pseudorabies Virus Recombinant Simultaneously Lacking the Major Tegument Proteins Encoded by the UL46, UL47, UL48, and UL49 Genes Is Viable in Cultured Cells J. Virol., December 1, 2003; 77(23): 12891 - 12900. [Abstract] [Full Text] [PDF]
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 S. Einav and J. S. Glenn Prenylation inhibitors: a novel class of antiviral agents J. Antimicrob. Chemother., December 1, 2003; 52(6): 883 - 886. [Abstract] [Full Text] [PDF]
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R. L. Thompson, M. T. Shieh, and N. M. Sawtell Analysis of Herpes Simplex Virus ICP0 Promoter Function in Sensory Neurons during Acute Infection, Establishment of Latency, and Reactivation In Vivo J. Virol., November 15, 2003; 77(22): 12319 - 12330. [Abstract] [Full Text] [PDF]
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E. Murphy, I. Rigoutsos, T. Shibuya, and T. E. Shenk Reevaluation of human cytomegalovirus coding potential PNAS, November 11, 2003; 100(23): 13585 - 13590. [Abstract] [Full Text] [PDF]
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C. R. Brandt and A. W. Kolb Tyrosine 116 of the Herpes Simplex Virus Type 1 IE{alpha}22 Protein Is an Ocular Virulence Determinant and Potential Phosphorylation Site Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4601 - 4607. [Abstract] [Full Text] [PDF]
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D. M. Koelle, Z. Liu, C. L. McClurkan, R. C. Cevallos, J. Vieira, N. A. Hosken, C. A. Meseda, D. C. Snow, A. Wald, and L. Corey Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor PNAS, October 28, 2003; 100(22): 12899 - 12904. [Abstract] [Full Text] [PDF]
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K. D. Perkins, J. Gregonis, S. Borge, and S. A. Rice Transactivation of a Viral Target Gene by Herpes Simplex Virus ICP27 Is Posttranscriptional and Does Not Require the Endogenous Promoter or Polyadenylation Site J. Virol., September 15, 2003; 77(18): 9872 - 9884. [Abstract] [Full Text] [PDF]
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M. Schelhaas, M. Jansen, I. Haase, and D. Knebel-Morsdorf Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells J. Gen. Virol., September 1, 2003; 84(9): 2473 - 2484. [Abstract] [Full Text] [PDF]
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A. Zago and P. G. Spear Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells J. Virol., September 1, 2003; 77(17): 9695 - 9699. [Abstract] [Full Text] [PDF]
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