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J Gen Virol 69 (1988), 1531-1574; DOI 10.1099/0022-1317-69-7-1531
© 1988 Society for General Microbiology

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The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

D. J. McGeoch, M. A. Dalrymple{dagger}, A. J. Davison, A. Dolan, M. C. Frame{ddagger}, D. McNab, L. J. Perry§, J. E. Scott and P. Taylor

MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

We have determined the DNA sequence of the long unique region (UL) in the genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained 107943 residues and had a base composition of 66.9% G+C. Together with our previous work, this completes the sequence of HSV-1 DNA, giving a total genome length of 152260 residues of base composition 68.3% G+C. Genes in the UL region were located by the use of published mapping analyses, transcript structures and sequence data, and by examination of DNA sequence characteristics. Fifty-six genes were identified, accounting for most of the sequence. Some 28 of these are at present of unknown function. The gene layout for UL was found to be very similar to that for the corresponding part of the genome of varicella-zoster virus, the only other completely sequenced alphaherpesvirus, and the amino acid sequences of equivalent proteins showed a range of similarities. In the whole genome of HSV-1 we now recognize 72 genes which encode 70 distinct proteins.

Keywords: DNA sequence, HSV-1, gene organization

{dagger} Present address: Department of Molecular Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, U.K.

{ddagger} Present address: Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, U.K.

§ Present address: Plant Breeding Institute, Maris Lane, Trumpington, Cambridge CB2 2LQ, U.K.

Received 22 February 1988; accepted 11 April 1988.


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W. Fuchs, H. Granzow, R. Klopfleisch, B. G. Klupp, D. Rosenkranz, and T. C. Mettenleiter
The UL7 Gene of Pseudorabies Virus Encodes a Nonessential Structural Protein Which Is Involved in Virion Formation and Egress
J. Virol., September 1, 2005; 79(17): 11291 - 11299.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
A. Kato, M. Yamamoto, T. Ohno, H. Kodaira, Y. Nishiyama, and Y. Kawaguchi
Identification of Proteins Phosphorylated Directly by the Us3 Protein Kinase Encoded by Herpes Simplex Virus 1
J. Virol., July 15, 2005; 79(14): 9325 - 9331.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
A. P. W. Poon and B. Roizman
Herpes Simplex Virus 1 ICP22 Regulates the Accumulation of a Shorter mRNA and of a Truncated US3 Protein Kinase That Exhibits Altered Functions
J. Virol., July 1, 2005; 79(13): 8470 - 8479.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
J. W. Drake and C. B. C. Hwang
On the Mutation Rate of Herpes Simplex Virus Type 1
Genetics, June 1, 2005; 170(2): 969 - 970.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
J. C. Yedowitz, A. Kotsakis, E. F. M. Schlegel, and J. A. Blaho
Nuclear Localizations of the Herpes Simplex Virus Type 1 Tegument Proteins VP13/14, vhs, and VP16 Precede VP22-Dependent Microtubule Reorganization and VP22 Nuclear Import
J. Virol., April 15, 2005; 79(8): 4730 - 4743.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
B. G. Klupp, H. Granzow, R. Klopfleisch, W. Fuchs, M. Kopp, M. Lenk, and T. C. Mettenleiter
Functional Analysis of the Pseudorabies Virus UL51 Protein
J. Virol., March 15, 2005; 79(6): 3831 - 3840.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
M. Hutoran, A. Ronen, A. Perelberg, M. Ilouze, A. Dishon, I. Bejerano, N. Chen, and M. Kotler
Description of an as Yet Unclassified DNA Virus from Diseased Cyprinus carpio Species
J. Virol., February 15, 2005; 79(4): 1983 - 1991.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
K. S. Trego, Y. Zhu, and D. S. Parris
The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA
Nucleic Acids Res., January 26, 2005; 33(2): 536 - 545.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
W. Fuchs, D. Wiesner, J. Veits, J. P. Teifke, and T. C. Mettenleiter
In Vitro and In Vivo Relevance of Infectious Laryngotracheitis Virus gJ Proteins That Are Expressed from Spliced and Nonspliced mRNAs
J. Virol., January 15, 2005; 79(2): 705 - 716.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
J. K. Thurlow, F. J. Rixon, M. Murphy, P. Targett-Adams, M. Hughes, and V. G. Preston
The Herpes Simplex Virus Type 1 DNA Packaging Protein UL17 Is a Virion Protein That Is Present in Both the Capsid and the Tegument Compartments
J. Virol., January 1, 2005; 79(1): 150 - 158.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
C. M. Preston and M. J. Nicholl
Human Cytomegalovirus Tegument Protein pp71 Directs Long-Term Gene Expression from Quiescent Herpes Simplex Virus Genomes
J. Virol., January 1, 2005; 79(1): 525 - 535.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
I. M. Porter and N. D. Stow
Replication, recombination and packaging of amplicon DNA in cells infected with the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12
J. Gen. Virol., December 1, 2004; 85(12): 3501 - 3510.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
W. Fuchs, B. G. Klupp, H. Granzow, and T. C. Mettenleiter
Essential Function of the Pseudorabies Virus UL36 Gene Product Is Independent of Its Interaction with the UL37 Protein
J. Virol., November 1, 2004; 78(21): 11879 - 11889.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
P. Norberg, T. Bergstrom, E. Rekabdar, M. Lindh, and J.-A. Liljeqvist
Phylogenetic Analysis of Clinical Herpes Simplex Virus Type 1 Isolates Identified Three Genetic Groups and Recombinant Viruses
J. Virol., October 1, 2004; 78(19): 10755 - 10764.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
P. E. Boehmer
RNA binding and R-loop formation by the herpes simplex virus type-1 single-stranded DNA-binding protein (ICP8)
Nucleic Acids Res., August 25, 2004; 32(15): 4576 - 4584.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
E. Avitabile, G. Lombardi, T. Gianni, M. Capri, and G. Campadelli-Fiume
Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression
J. Virol., August 1, 2004; 78(15): 8015 - 8025.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
H. Augustinova, D. Hoeller, and F. Yao
The Dominant-Negative Herpes Simplex Virus Type 1 (HSV-1) Recombinant CJ83193 Can Serve as an Effective Vaccine against Wild-Type HSV-1 Infection in Mice
J. Virol., June 1, 2004; 78(11): 5756 - 5765.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
T. J. Taylor and D. M. Knipe
Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteins with ICP8
J. Virol., June 1, 2004; 78(11): 5856 - 5866.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
R. Klopfleisch, J. P. Teifke, W. Fuchs, M. Kopp, B. G. Klupp, and T. C. Mettenleiter
Influence of Tegument Proteins of Pseudorabies Virus on Neuroinvasion and Transneuronal Spread in the Nervous System of Adult Mice after Intranasal Inoculation
J. Virol., March 15, 2004; 78(6): 2956 - 2966.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
I. M. Porter and N. D. Stow
Virus particles produced by the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 contain abnormal genomes
J. Gen. Virol., March 1, 2004; 85(3): 583 - 591.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
R. Hagglund and B. Roizman
Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1
J. Virol., March 1, 2004; 78(5): 2169 - 2178.
[Full Text] [PDF]


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IOVSHome page
Y. Osorio, J. Cohen, and H. Ghiasi
Improved Protection from Primary Ocular HSV-1 Infection and Establishment of Latency Using Multigenic DNA Vaccines
Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 506 - 514.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
H. Granzow, B. G. Klupp, and T. C. Mettenleiter
The Pseudorabies Virus US3 Protein Is a Component of Primary and of Mature Virions
J. Virol., February 1, 2004; 78(3): 1314 - 1323.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
H. Browne, S. Bell, and T. Minson
Analysis of the Requirement for Glycoprotein M in Herpes Simplex Virus Type 1 Morphogenesis
J. Virol., January 15, 2004; 78(2): 1039 - 1041.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
C. M. Sanfilippo, F. N. W. Chirimuuta, and J. A. Blaho
Herpes Simplex Virus Type 1 Immediate-Early Gene Expression Is Required for the Induction of Apoptosis in Human Epithelial HEp-2 Cells
J. Virol., January 1, 2004; 78(1): 224 - 239.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
B. G. Klupp, C. J. Hengartner, T. C. Mettenleiter, and L. W. Enquist
Complete, Annotated Sequence of the Pseudorabies Virus Genome
J. Virol., January 1, 2004; 78(1): 424 - 440.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
B. G. Klupp, H. Granzow, W. Fuchs, E. Mundt, and T. C. Mettenleiter
Pseudorabies Virus UL3 Gene Codes for a Nuclear Protein Which Is Dispensable for Viral Replication
J. Virol., January 1, 2004; 78(1): 464 - 472.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
J. Veits, D. Luschow, K. Kindermann, O. Werner, J. P. Teifke, T. C. Mettenleiter, and W. Fuchs
Deletion of the non-essential UL0 gene of infectious laryngotracheitis (ILT) virus leads to attenuation in chickens, and UL0 mutants expressing influenza virus haemagglutinin (H7) protect against ILT and fowl plague
J. Gen. Virol., December 1, 2003; 84(12): 3343 - 3352.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
W. Fuchs, H. Granzow, and T. C. Mettenleiter
A Pseudorabies Virus Recombinant Simultaneously Lacking the Major Tegument Proteins Encoded by the UL46, UL47, UL48, and UL49 Genes Is Viable in Cultured Cells
J. Virol., December 1, 2003; 77(23): 12891 - 12900.
[Abstract] [Full Text] [PDF]


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J Antimicrob ChemotherHome page
S. Einav and J. S. Glenn
Prenylation inhibitors: a novel class of antiviral agents
J. Antimicrob. Chemother., December 1, 2003; 52(6): 883 - 886.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
R. L. Thompson, M. T. Shieh, and N. M. Sawtell
Analysis of Herpes Simplex Virus ICP0 Promoter Function in Sensory Neurons during Acute Infection, Establishment of Latency, and Reactivation In Vivo
J. Virol., November 15, 2003; 77(22): 12319 - 12330.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
E. Murphy, I. Rigoutsos, T. Shibuya, and T. E. Shenk
Reevaluation of human cytomegalovirus coding potential
PNAS, November 11, 2003; 100(23): 13585 - 13590.
[Abstract] [Full Text] [PDF]


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IOVSHome page
C. R. Brandt and A. W. Kolb
Tyrosine 116 of the Herpes Simplex Virus Type 1 IE{alpha}22 Protein Is an Ocular Virulence Determinant and Potential Phosphorylation Site
Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4601 - 4607.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
D. M. Koelle, Z. Liu, C. L. McClurkan, R. C. Cevallos, J. Vieira, N. A. Hosken, C. A. Meseda, D. C. Snow, A. Wald, and L. Corey
Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
PNAS, October 28, 2003; 100(22): 12899 - 12904.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
K. D. Perkins, J. Gregonis, S. Borge, and S. A. Rice
Transactivation of a Viral Target Gene by Herpes Simplex Virus ICP27 Is Posttranscriptional and Does Not Require the Endogenous Promoter or Polyadenylation Site
J. Virol., September 15, 2003; 77(18): 9872 - 9884.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
M. Schelhaas, M. Jansen, I. Haase, and D. Knebel-Morsdorf
Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells
J. Gen. Virol., September 1, 2003; 84(9): 2473 - 2484.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
A. Zago and P. G. Spear
Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells
J. Virol., September 1, 2003; 77(17): 9695 - 9699.
[Abstract] [Full Text] [PDF]




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