| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.
We have determined the DNA sequence of the long unique region (UL) in the genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained 107943 residues and had a base composition of 66.9% G+C. Together with our previous work, this completes the sequence of HSV-1 DNA, giving a total genome length of 152260 residues of base composition 68.3% G+C. Genes in the UL region were located by the use of published mapping analyses, transcript structures and sequence data, and by examination of DNA sequence characteristics. Fifty-six genes were identified, accounting for most of the sequence. Some 28 of these are at present of unknown function. The gene layout for UL was found to be very similar to that for the corresponding part of the genome of varicella-zoster virus, the only other completely sequenced alphaherpesvirus, and the amino acid sequences of equivalent proteins showed a range of similarities. In the whole genome of HSV-1 we now recognize 72 genes which encode 70 distinct proteins.
Keywords: DNA sequence, HSV-1, gene organization
Present address: Department of Molecular Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, U.K.
Present address: Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, U.K.
Present address: Plant Breeding Institute, Maris Lane, Trumpington, Cambridge CB2 2LQ, U.K.
Received 22 February 1988;
accepted 11 April 1988.
This article has been cited by other articles:
|
|
 |
|
  V. G. Preston, J. Murray, C. M. Preston, I. M. McDougall, and N. D. Stow The UL25 Gene Product of Herpes Simplex Virus Type 1 Is Involved in Uncoating of the Viral Genome J. Virol., July 1, 2008; 82(13): 6654 - 6666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Krautwald, C. Maresch, B. G. Klupp, W. Fuchs, and T. C. Mettenleiter Deletion or green fluorescent protein tagging of the pUL35 capsid component of pseudorabies virus impairs virus replication in cell culture and neuroinvasion in mice J. Gen. Virol., June 1, 2008; 89(6): 1346 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ushijima, T. Koshizuka, F. Goshima, H. Kimura, and Y. Nishiyama Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases Its Ubiquitination J. Virol., June 1, 2008; 82(11): 5220 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Umene, S. Oohashi, M. Yoshida, and Y. Fukumaki Diversity of the a sequence of herpes simplex virus type 1 developed during evolution J. Gen. Virol., April 1, 2008; 89(4): 841 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Nagel, K. Dohner, M. Fathollahy, T. Strive, E. M. Borst, M. Messerle, and B. Sodeik Nuclear Egress and Envelopment of Herpes Simplex Virus Capsids Analyzed with Dual-Color Fluorescence HSV1(17+) J. Virol., March 15, 2008; 82(6): 3109 - 3124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sampath and N. A. DeLuca Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells J. Virol., March 1, 2008; 82(5): 2339 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yang, A. P. W. Poon, B. Roizman, and J. D. Baines Temperature-Sensitive Mutations in the Putative Herpes Simplex Virus Type 1 Terminase Subunits pUL15 and pUL33 Preclude Viral DNA Cleavage/Packaging and Interaction with pUL28 at the Nonpermissive Temperature J. Virol., January 1, 2008; 82(1): 487 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Mott, G.-C. Perng, Y. Osorio, K. G. Kousoulas, and H. Ghiasi A Recombinant Herpes Simplex Virus Type 1 Expressing Two Additional Copies of gK Is More Pathogenic than Wild-Type Virus in Two Different Strains of Mice J. Virol., December 1, 2007; 81(23): 12962 - 12972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Tarr, A. M. Owsianka, D. Jayaraj, R. J. P. Brown, T. P. Hickling, W. L. Irving, A. H. Patel, and J. K. Ball Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33 J. Gen. Virol., November 1, 2007; 88(11): 2991 - 3001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, J. Murray, A. Orr, and C. M. Preston Herpes Simplex Virus Type 1 Genomes Are Associated with ND10 Nuclear Substructures in Quiescently Infected Human Fibroblasts J. Virol., October 15, 2007; 81(20): 10991 - 11004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Markovitz The Herpes Simplex Virus Type 1 UL3 Transcript Starts within the UL3 Open Reading Frame and Encodes a 224-Amino-Acid Protein J. Virol., October 1, 2007; 81(19): 10524 - 10531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Iwahori, N. Shirata, Y. Kawaguchi, S. K. Weller, Y. Sato, A. Kudoh, S. Nakayama, H. Isomura, and T. Tsurumi Enhanced Phosphorylation of Transcription Factor Sp1 in Response to Herpes Simplex Virus Type 1 Infection Is Dependent on the Ataxia Telangiectasia-Mutated Protein J. Virol., September 15, 2007; 81(18): 9653 - 9664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, H. Granzow, B. G. Klupp, A. Karger, K. Michael, C. Maresch, R. Klopfleisch, and T. C. Mettenleiter Relevance of the Interaction between Alphaherpesvirus UL3.5 and UL48 Proteins for Virion Maturation and Neuroinvasion J. Virol., September 1, 2007; 81(17): 9307 - 9318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Bertke, A. Patel, and P. R. Krause Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism J. Virol., June 15, 2007; 81(12): 6605 - 6613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mou, T. Forest, and J. D. Baines US3 of Herpes Simplex Virus Type 1 Encodes a Promiscuous Protein Kinase That Phosphorylates and Alters Localization of Lamin A/C in Infected Cells J. Virol., June 15, 2007; 81(12): 6459 - 6470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Norberg, S. Olofsson, M. A. Tarp, H. Clausen, T. Bergstrom, and J. A. Liljeqvist Glycoprotein I of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region J. Gen. Virol., June 1, 2007; 88(6): 1683 - 1688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gershburg, S. Raffa, M. R. Torrisi, and J. S. Pagano Epstein-Barr Virus-Encoded Protein Kinase (BGLF4) Is Involved in Production of Infectious Virus J. Virol., May 15, 2007; 81(10): 5407 - 5412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Mott, Y. Osorio, E. Maguen, A. B. Nesburn, A. E. Wittek, S. Cai, S. Chattopadhyay, and H. Ghiasi Role of Anti-Glycoproteins D (Anti-gD) and K (Anti-gK) IgGs in Pathology of Herpes Stromal Keratitis in Humans Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2185 - 2193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Prichard, K. A. Keith, M. P. Johnson, E. A. Harden, A. McBrayer, M. Luo, S. Qiu, D. Chattopadhyay, X. Fan, P. F. Torrence, et al. Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase Antimicrob. Agents Chemother., May 1, 2007; 51(5): 1795 - 1803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jiang, Y. T. Hwang, J. C. W. Randell, D. M. Coen, and C. B. C. Hwang Mutations That Decrease DNA Binding of the Processivity Factor of the Herpes Simplex Virus DNA Polymerase Reduce Viral Yield, Alter the Kinetics of Viral DNA Replication, and Decrease the Fidelity of DNA Replication J. Virol., April 1, 2007; 81(7): 3495 - 3502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Baines, C.-E. Hsieh, E. Wills, C. Mannella, and M. Marko Electron Tomography of Nascent Herpes Simplex Virus Virions J. Virol., March 15, 2007; 81(6): 2726 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Helferich, J. Veits, T. C. Mettenleiter, and W. Fuchs Identification of transcripts and protein products of the UL31, UL37, UL46, UL47, UL48, UL49 and US4 gene homologues of avian infectious laryngotracheitis virus J. Gen. Virol., March 1, 2007; 88(3): 719 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Helferich, J. Veits, J. P. Teifke, T. C. Mettenleiter, and W. Fuchs The UL47 gene of avian infectious laryngotracheitis virus is not essential for in vitro replication but is relevant for virulence in chickens J. Gen. Virol., March 1, 2007; 88(3): 732 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Eda, S. Ozawa, K. Yoshino, K. Yanagi, and the Cooperation Group for HSV-1 RFLP Variant Study Contrasting Geographic Distribution Profiles of the Herpes Simplex Virus Type 1 BgOL and BgKL Variants in Japan Suggest Dispersion and Replacement J. Clin. Microbiol., March 1, 2007; 45(3): 771 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Strang and N. D. Stow Blocks to herpes simplex virus type 1 replication in a cell line, tsBN2, encoding a temperature-sensitive RCC1 protein J. Gen. Virol., February 1, 2007; 88(2): 376 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Baines, E. Wills, R. J. Jacob, J. Pennington, and B. Roizman Glycoprotein M of Herpes Simplex Virus 1 Is Incorporated into Virions during Budding at the Inner Nuclear Membrane J. Virol., January 15, 2007; 81(2): 800 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Jacobson, K. Yang, J. D. Baines, and F. L. Homa Linker Insertion Mutations in the Herpes Simplex Virus Type 1 UL28 Gene: Effects on UL28 Interaction with UL15 and UL33 and Identification of a Second-Site Mutation in the UL15 Gene That Suppresses a Lethal UL28 Mutation J. Virol., December 15, 2006; 80(24): 12312 - 12323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Thompson and N. M. Sawtell Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo J. Virol., November 15, 2006; 80(22): 10919 - 10930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ehlers, G. Dural, M. Marschall, V. Schregel, M. Goltz, and J. Hentschke Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene. J. Gen. Virol., October 1, 2006; 87(Pt 10): 2781 - 2789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, H. Granzow, R. Klopfleisch, B. G. Klupp, and T. C. Mettenleiter The UL4 gene of pseudorabies virus encodes a minor infected-cell protein that is dispensable for virus replication J. Gen. Virol., September 1, 2006; 87(9): 2517 - 2525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Duffy, J. H. LaVail, A. N. Tauscher, E. G. Wills, J. A. Blaho, and J. D. Baines Characterization of a UL49-Null Mutant: VP22 of Herpes Simplex Virus Type 1 Facilitates Viral Spread in Cultured Cells and the Mouse Cornea. J. Virol., September 1, 2006; 80(17): 8664 - 8675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Loregian, A. Case, E. Cancellotti, C. Valente, H. S. Marsden, and G. Palu Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit. J. Virol., July 1, 2006; 80(13): 6247 - 6258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Han and S. Swaminathan Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene ORF57 Is Essential for Infectious Virion Production. J. Virol., June 1, 2006; 80(11): 5251 - 5260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yang and J. D. Baines The Putative Terminase Subunit of Herpes Simplex Virus 1 Encoded by UL28 Is Necessary and Sufficient To Mediate Interaction between pUL15 and pUL33. J. Virol., June 1, 2006; 80(12): 5733 - 5739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Shogan, L. Kruse, G. B. Mulamba, A. Hu, and D. M. Coen Virucidal Activity of a GT-Rich Oligonucleotide against Herpes Simplex Virus Mediated by Glycoprotein B. J. Virol., May 1, 2006; 80(10): 4740 - 4747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Che, L. Zerboni, M. H. Sommer, and A. M. Arvin Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivo. J. Virol., April 1, 2006; 80(7): 3238 - 3248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. W. Poon, L. Benetti, and B. Roizman US3 and US3.5 Protein Kinases of Herpes Simplex Virus 1 Differ with Respect to Their Functions in Blocking Apoptosis and in Virion Maturation and Egress. J. Virol., April 1, 2006; 80(8): 3752 - 3764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Thurlow, M. Murphy, N. D. Stow, and V. G. Preston Herpes Simplex Virus Type 1 DNA-Packaging Protein UL17 Is Required for Efficient Binding of UL25 to Capsids J. Virol., March 1, 2006; 80(5): 2118 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Bowman, R. L. Welschhans, H. Jayaram, N. D. Stow, V. G. Preston, and F. A. Quiocho Structural Characterization of the UL25 DNA-Packaging Protein from Herpes Simplex Virus Type 1 J. Virol., March 1, 2006; 80(5): 2309 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Tyler and A. Severini The Complete Genome Sequence of Herpesvirus Papio 2 (Cercopithecine Herpesvirus 16) Shows Evidence of Recombination Events among Various Progenitor Herpesviruses J. Virol., February 1, 2006; 80(3): 1214 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Okoye, G. L. Sexton, E. Huang, J. M. McCaffery, and P. Desai Functional Analysis of the Triplex Proteins (VP19C and VP23) of Herpes Simplex Virus Type 1 J. Virol., January 15, 2006; 80(2): 929 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Sawtell, R. L. Thompson, and R. L. Haas Herpes Simplex Virus DNA Synthesis Is Not a Decisive Regulatory Event in the Initiation of Lytic Viral Protein Expression in Neurons In Vivo during Primary Infection or Reactivation from Latency J. Virol., January 1, 2006; 80(1): 38 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Davison and N. D. Stow New Genes from Old: Redeployment of dUTPase by Herpesviruses J. Virol., October 15, 2005; 79(20): 12880 - 12892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Glauser, O. Saydam, N. A. Balsiger, I. Heid, R. M. Linden, M. Ackermann, and C. Fraefel Four-Dimensional Visualization of the Simultaneous Activity of Alternative Adeno-Associated Virus Replication Origins J. Virol., October 1, 2005; 79(19): 12218 - 12230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Strang and N. D. Stow Circularization of the Herpes Simplex Virus Type 1 Genome upon Lytic Infection J. Virol., October 1, 2005; 79(19): 12487 - 12494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Pomeranz, A. E. Reynolds, and C. J. Hengartner Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine Microbiol. Mol. Biol. Rev., September 1, 2005; 69(3): 462 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, H. Granzow, R. Klopfleisch, B. G. Klupp, D. Rosenkranz, and T. C. Mettenleiter The UL7 Gene of Pseudorabies Virus Encodes a Nonessential Structural Protein Which Is Involved in Virion Formation and Egress J. Virol., September 1, 2005; 79(17): 11291 - 11299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kato, M. Yamamoto, T. Ohno, H. Kodaira, Y. Nishiyama, and Y. Kawaguchi Identification of Proteins Phosphorylated Directly by the Us3 Protein Kinase Encoded by Herpes Simplex Virus 1 J. Virol., July 15, 2005; 79(14): 9325 - 9331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. W. Poon and B. Roizman Herpes Simplex Virus 1 ICP22 Regulates the Accumulation of a Shorter mRNA and of a Truncated US3 Protein Kinase That Exhibits Altered Functions J. Virol., July 1, 2005; 79(13): 8470 - 8479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Drake and C. B. C. Hwang On the Mutation Rate of Herpes Simplex Virus Type 1 Genetics, June 1, 2005; 170(2): 969 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Yedowitz, A. Kotsakis, E. F. M. Schlegel, and J. A. Blaho Nuclear Localizations of the Herpes Simplex Virus Type 1 Tegument Proteins VP13/14, vhs, and VP16 Precede VP22-Dependent Microtubule Reorganization and VP22 Nuclear Import J. Virol., April 15, 2005; 79(8): 4730 - 4743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Klupp, H. Granzow, R. Klopfleisch, W. Fuchs, M. Kopp, M. Lenk, and T. C. Mettenleiter Functional Analysis of the Pseudorabies Virus UL51 Protein J. Virol., March 15, 2005; 79(6): 3831 - 3840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hutoran, A. Ronen, A. Perelberg, M. Ilouze, A. Dishon, I. Bejerano, N. Chen, and M. Kotler Description of an as Yet Unclassified DNA Virus from Diseased Cyprinus carpio Species J. Virol., February 15, 2005; 79(4): 1983 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Trego, Y. Zhu, and D. S. Parris The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA Nucleic Acids Res., January 26, 2005; 33(2): 536 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, D. Wiesner, J. Veits, J. P. Teifke, and T. C. Mettenleiter In Vitro and In Vivo Relevance of Infectious Laryngotracheitis Virus gJ Proteins That Are Expressed from Spliced and Nonspliced mRNAs J. Virol., January 15, 2005; 79(2): 705 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Thurlow, F. J. Rixon, M. Murphy, P. Targett-Adams, M. Hughes, and V. G. Preston The Herpes Simplex Virus Type 1 DNA Packaging Protein UL17 Is a Virion Protein That Is Present in Both the Capsid and the Tegument Compartments J. Virol., January 1, 2005; 79(1): 150 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston and M. J. Nicholl Human Cytomegalovirus Tegument Protein pp71 Directs Long-Term Gene Expression from Quiescent Herpes Simplex Virus Genomes J. Virol., January 1, 2005; 79(1): 525 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Porter and N. D. Stow Replication, recombination and packaging of amplicon DNA in cells infected with the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 J. Gen. Virol., December 1, 2004; 85(12): 3501 - 3510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, B. G. Klupp, H. Granzow, and T. C. Mettenleiter Essential Function of the Pseudorabies Virus UL36 Gene Product Is Independent of Its Interaction with the UL37 Protein J. Virol., November 1, 2004; 78(21): 11879 - 11889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Norberg, T. Bergstrom, E. Rekabdar, M. Lindh, and J.-A. Liljeqvist Phylogenetic Analysis of Clinical Herpes Simplex Virus Type 1 Isolates Identified Three Genetic Groups and Recombinant Viruses J. Virol., October 1, 2004; 78(19): 10755 - 10764. [Abstract] [Full Text] [PDF]
|
|
