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Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
The primary infection of BALB/c mice with murine herpesvirus 68 (MHV-68) was investigated. When the virus was introduced intranasally, the lung was the main tissue infected, the virus being associated with alveolar epithelium and mononuclear cells. A productive infection lasted for 10 days, after which viral DNA could be detected by in situ hybridization up to 30 days after infection. At that time lymphoproliferative accumulations were also observed in the lung, with formation of germinal centres. Virus could also be recovered from the heart, kidney, adrenal gland and spleen during the primary infection. In addition, the spleen appeared to be the major site of virus persistence, with latently infected cells detected up to 90 days post-infection. During the primary infection, there was atrophy of the thymus and spleen of clinically sick animals. In contrast, lymphoproliferative responses, typified by splenomegaly, were frequently seen in asymptomatic animals. The pattern of infection observed in MHV-68-infected mice is similar to that seen in infectious mononucleosis of man following Epstein—Barr virus infection. The model described in this paper may prove to be useful in studying natural gamma-herpesvirus infections of man and domestic animals.
Present address: Herpesvirus Laboratory, Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia.
Received 27 February 1992;
accepted 15 May 1992.
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S. A. Tibbetts, J. S. McClellan, S. Gangappa, S. H. Speck, and H. W. Virgin IV Effective Vaccination against Long-Term Gammaherpesvirus Latency J. Virol., February 15, 2003; 77(4): 2522 - 2529. [Abstract] [Full Text] [PDF]
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K. Blasdell, C. McCracken, A. Morris, A. A. Nash, M. Begon, M. Bennett, and J. P. Stewart The wood mouse is a natural host for Murid herpesvirus 4 J. Gen. Virol., January 1, 2003; 84(1): 111 - 113. [Abstract] [Full Text] [PDF]
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S. Gangappa, S. B. Kapadia, S. H. Speck, and H. W. Virgin IV Antibody to a Lytic Cycle Viral Protein Decreases Gammaherpesvirus Latency in B-Cell-Deficient Mice J. Virol., November 15, 2002; 76(22): 11460 - 11468. [Abstract] [Full Text] [PDF]
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J. B. Weinberg, M. L. Lutzke, S. Efstathiou, S. L. Kunkel, and R. Rochford Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection J. Virol., October 15, 2002; 76(20): 10518 - 10523. [Abstract] [Full Text] [PDF]
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S. A. Tibbetts, L. F. van Dyk, S. H. Speck, and H. W. Virgin IV Immune Control of the Number and Reactivation Phenotype of Cells Latently Infected with a Gammaherpesvirus J. Virol., July 15, 2002; 76(14): 7125 - 7132. [Abstract] [Full Text] [PDF]
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E. T. Clambey, H. W. Virgin IV, and S. H. Speck Characterization of a Spontaneous 9.5-Kilobase-Deletion Mutant of Murine Gammaherpesvirus 68 Reveals Tissue-Specific Genetic Requirements for Latency J. Virol., July 1, 2002; 76(13): 6532 - 6544. [Abstract] [Full Text] [PDF]
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 D. G. Alber, P. Vallance, and K. L. Powell Enhanced Atherogenesis Is Not an Obligatory Response to Systemic Herpesvirus Infection in the ApoE-Deficient Mouse: Comparison of Murine {gamma}-Herpesvirus-68 and Herpes Simplex Virus-1 Arterioscler Thromb Vasc Biol, May 1, 2002; 22(5): 793 - 798. [Abstract] [Full Text] [PDF]
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M. A. Jacoby, H. W. Virgin IV, and S. H. Speck Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency following Intranasal, but Not Intraperitoneal, Inoculation J. Virol., February 15, 2002; 76(4): 1790 - 1801. [Abstract] [Full Text] [PDF]
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C. M. Payne, C. J. Heggie, D. G. Brownstein, J. P. Stewart, and J. P. Quinn Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection J. Virol., November 1, 2001; 75(21): 10467 - 10471. [Abstract] [Full Text] [PDF]
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T.-T. Wu, L. Tong, T. Rickabaugh, S. Speck, and R. Sun Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68 J. Virol., October 1, 2001; 75(19): 9262 - 9273. [Abstract] [Full Text] [PDF]
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E. J. Usherwood, K. A. Ward, M. A. Blackman, J. P. Stewart, and D. L. Woodland Latent Antigen Vaccination in a Model Gammaherpesvirus Infection J. Virol., September 1, 2001; 75(17): 8283 - 8288. [Abstract] [Full Text] [PDF]
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R. Rochford, M. L. Lutzke, R. S. Alfinito, A. Clavo, and R. D. Cardin Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice J. Virol., June 1, 2001; 75(11): 4955 - 4963. [Abstract] [Full Text] [PDF]
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A. I. Macrae, B. M. Dutia, S. Milligan, D. G. Brownstein, D. J. Allen, J. Mistrikova, A. J. Davison, A. A. Nash, and J. P. Stewart Analysis of a Novel Strain of Murine Gammaherpesvirus Reveals a Genomic Locus Important for Acute Pathogenesis J. Virol., June 1, 2001; 75(11): 5315 - 5327. [Abstract] [Full Text] [PDF]
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 B. Ebrahimi, B. M. Dutia, D. G. Brownstein, and A. A. Nash Murine Gammaherpesvirus-68 Infection Causes Multi-Organ Fibrosis and Alters Leukocyte Trafficking in Interferon-{{gamma}} Receptor Knockout Mice Am. J. Pathol., June 1, 2001; 158(6): 2117 - 2125. [Abstract] [Full Text] [PDF]
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M. N. Wakeling, D. J. Roy, A. A. Nash, and J. P. Stewart Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor J. Gen. Virol., May 1, 2001; 82(5): 1187 - 1197. [Abstract] [Full Text]
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K. M. Haan, A. Aiyar, and R. Longnecker Establishment of Latent Epstein-Barr Virus Infection and Stable Episomal Maintenance in Murine B-Cell Lines J. Virol., March 15, 2001; 75(6): 3016 - 3020. [Abstract] [Full Text] [PDF]
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L. A. Terry, J. P. Stewart, A. A. Nash, and J. K. Fazakerley Murine gammaherpesvirus-68 infection of and persistence in the central nervous system J. Gen. Virol., November 1, 2000; 81(11): 2635 - 2643. [Abstract] [Full Text]
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 E. J. Usherwood, D. J. Roy, K. Ward, S. L. Surman, B. M. Dutia, M. A. Blackman, J. P. Stewart, and D. L. Woodland Control of Gammaherpesvirus Latency by Latent Antigen-Specific Cd8+ T Cells J. Exp. Med., October 2, 2000; 192(7): 943 - 952. [Abstract] [Full Text] [PDF]
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 D. G. Alber, K. L. Powell, P. Vallance, D. A. Goodwin, and C. Grahame-Clarke Herpesvirus Infection Accelerates Atherosclerosis in the Apolipoprotein E-Deficient Mouse Circulation, August 15, 2000; 102(7): 779 - 785. [Abstract] [Full Text] [PDF]
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A. T. Hoge, S. B. Hendrickson, and W. H. Burns Murine Gammaherpesvirus 68 Cyclin D Homologue Is Required for Efficient Reactivation from Latency J. Virol., August 1, 2000; 74(15): 7016 - 7023. [Abstract] [Full Text] [PDF]
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 J. Goudsmit, N. Renwick, N. H. T. M. Dukers, R. A. Coutinho, S. Heisterkamp, M. Bakker, T. F. Schulz, M. Cornelissen, and G. J. Weverling Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984-1997): Analysis of seroconversions to ORF65 and ORF73 PNAS, April 25, 2000; 97(9): 4838 - 4843. [Abstract] [Full Text] [PDF]
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T.-T. Wu, E. J. Usherwood, J. P. Stewart, A. A. Nash, and R. Sun Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency J. Virol., April 15, 2000; 74(8): 3659 - 3667. [Abstract] [Full Text] [PDF]
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E. T. Clambey, H. W. Virgin IV, and S. H. Speck Disruption of the Murine Gammaherpesvirus 68 M1 Open Reading Frame Leads to Enhanced Reactivation from Latency J. Virol., February 15, 2000; 74(4): 1973 - 1984. [Abstract] [Full Text] [PDF]
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S. Liu, I. V. Pavlova, H. W. Virgin IV, and S. H. Speck Characterization of Gammaherpesvirus 68 Gene 50 Transcription J. Virol., February 15, 2000; 74(4): 2029 - 2037. [Abstract] [Full Text] [PDF]
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M. Y. Sangster, D. J. Topham, S. D'Costa, R. D. Cardin, T. N. Marion, L. K. Myers, and P. C. Doherty Analysis of the Virus-Specific and Nonspecific B Cell Response to a Persistent B-Lymphotropic Gammaherpesvirus J. Immunol., February 15, 2000; 164(4): 1820 - 1828. [Abstract] [Full Text] [PDF]
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J. W. Peacock and K. L. Bost Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine gammaherpesvirus-68 J. Gen. Virol., February 1, 2000; 81(2): 421 - 429. [Abstract] [Full Text]
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L. Liu, E. J. Usherwood, M. A. Blackman, and D. L. Woodland T-Cell Vaccination Alters the Course of Murine Herpesvirus 68 Infection and the Establishment of Viral Latency in Mice J. Virol., December 1, 1999; 73(12): 9849 - 9857. [Abstract] [Full Text] [PDF]
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L. J. Bello, A. J. Davison, M. A. Glenn, A. Whitehouse, N. Rethmeier, T. F. Schulz, and J. Barklie Clements The human herpesvirus-8 ORF 57 gene and its properties J. Gen. Virol., December 1, 1999; 80(12): 3207 - 3215. [Abstract] [Full Text]
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