| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Microbiology-Immunology, Northwestern University Medical and Dental Schools, 303 East Chicago Avenue, Chicago, Illinois 60611
and2 Department of Medical Microbiology/Immunology and Ophthalmology, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.
Previous studies have shown that the initial interaction of herpes simplex virus (HSV) with cells is binding to heparan sulphate and that HSV-1 glycoprotein C (gC) is principally responsible for this binding. Although gC-negative viral mutants are impaired for binding and entry, they retain significant infectivity. The purpose of the studies reported here was to explore the requirements for infectivity of gC-negative HSV-1 mutants. We found that absence or alteration of cell surface heparan sulphate significantly reduced the binding of gC-negative mutant virus and rendered cells resistant to infection, as shown previously for the wild-type virus. We isolated a recombinant double-mutated HSV strain that produces virions devoid of both of the known heparin-binding glycoproteins, gB and gC. The drastically impaired binding of these mutant virions to cells, relative to gC-negative and wild-type virions, indicates that gB mediates the binding of gC-negative virions to cells. Thus at least two HSV glycoproteins can independently mediate the binding of HSV to cell surface heparan sulphate to start the process of viral entry into cells.
Present address: Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, U.S.A.
Present address: Department of Microbiology-Immunology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, U.S.A.
Received 11 November 1993;
accepted 5 January 1994.
This article has been cited by other articles:
|
|
 |
|
  M. Aubert, M. Yoon, D. D. Sloan, P. G. Spear, and K. R. Jerome The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells J. Virol., June 15, 2009; 83(12): 6171 - 6183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Arii, M. Uema, T. Morimoto, H. Sagara, H. Akashi, E. Ono, H. Arase, and Y. Kawaguchi Entry of Herpes Simplex Virus 1 and Other Alphaherpesviruses via the Paired Immunoglobulin-Like Type 2 Receptor {alpha} J. Virol., May 1, 2009; 83(9): 4520 - 4527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mok, T. Stylianopoulos, Y. Boucher, and R. K. Jain Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy Clin. Cancer Res., April 1, 2009; 15(7): 2352 - 2360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gillet, J. S. May, and P. G. Stevenson In vivo importance of heparan sulfate-binding glycoproteins for murid herpesvirus-4 infection J. Gen. Virol., March 1, 2009; 90(3): 602 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Akkarawongsa, N. E. Pocaro, G. Case, A. W. Kolb, and C. R. Brandt Multiple Peptides Homologous to Herpes Simplex Virus Type 1 Glycoprotein B Inhibit Viral Infection Antimicrob. Agents Chemother., March 1, 2009; 53(3): 987 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ghosh, K. Chattopadhyay, M. Marschall, P. Karmakar, P. Mandal, and B. Ray Focus on antivirally active sulfated polysaccharides: From structure-activity analysis to clinical evaluation Glycobiology, January 1, 2009; 19(1): 2 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ono, Y. Tomioka, Y. Watanabe, K. Amagai, M. Morimatsu, K. Shinya, and P. Cherel Comparison of the antiviral potentials among the pseudorabies-resistant transgenes encoding different soluble forms of porcine nectin-1 in transgenic mice J. Gen. Virol., October 1, 2007; 88(10): 2636 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bultmann, J. Teuton, and C. R. Brandt Addition of a C-Terminal Cysteine Improves the Anti-Herpes Simplex Virus Activity of a Peptide Containing the Human Immunodeficiency Virus Type 1 TAT Protein Transduction Domain Antimicrob. Agents Chemother., May 1, 2007; 51(5): 1596 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Teuton and C. R. Brandt Sialic Acid on Herpes Simplex Virus Type 1 Envelope Glycoproteins Is Required for Efficient Infection of Cells J. Virol., April 15, 2007; 81(8): 3731 - 3739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hoppe, M. Schelhaas, V. Jaeger, T. Liebig, P. Petermann, and D. Knebel-Morsdorf Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells J. Gen. Virol., December 1, 2006; 87(12): 3483 - 3494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gianni, R. Fato, C. Bergamini, G. Lenaz, and G. Campadelli-Fiume Hydrophobic {alpha}-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion. J. Virol., August 1, 2006; 80(16): 8190 - 8198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Zautner, B. Jahn, E. Hammerschmidt, P. Wutzler, and M. Schmidtke N- and 6-O-Sulfated Heparan Sulfates Mediate Internalization of Coxsackievirus B3 Variant PD into CHO-K1 Cells. J. Virol., July 1, 2006; 80(13): 6629 - 6636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Tyler and A. Severini The Complete Genome Sequence of Herpesvirus Papio 2 (Cercopithecine Herpesvirus 16) Shows Evidence of Recombination Events among Various Progenitor Herpesviruses J. Virol., February 1, 2006; 80(3): 1214 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Sloan, J.-Y. Han, T. K. Sandifer, M. Stewart, A. J. Hinz, M. Yoon, D. C. Johnson, P. G. Spear, and K. R. Jerome Inhibition of TCR Signaling by Herpes Simplex Virus J. Immunol., February 1, 2006; 176(3): 1825 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kwon, Q. Bai, H.-J. Baek, K. Felmet, E. A. Burton, W. F. Goins, J. B. Cohen, and J. C. Glorioso Soluble V Domain of Nectin-1/HveC Enables Entry of Herpes Simplex Virus Type 1 (HSV-1) into HSV-Resistant Cells by Binding to Viral Glycoprotein D J. Virol., January 1, 2006; 80(1): 138 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Bender, J. C. Whitbeck, H. Lou, G. H. Cohen, and R. J. Eisenberg Herpes Simplex Virus Glycoprotein B Binds to Cell Surfaces Independently of Heparan Sulfate and Blocks Virus Entry J. Virol., September 15, 2005; 79(18): 11588 - 11597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cheshenko, W. Liu, L. M. Satlin, and B. C. Herold Focal Adhesion Kinase Plays a Pivotal Role in Herpes Simplex Virus Entry J. Biol. Chem., September 2, 2005; 280(35): 31116 - 31125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ono, K. Amagai, S. Taharaguchi, Y. Tomioka, S. Yoshino, Y. Watanabe, P. Cherel, L.-M. Houdebine, M. Adam, M. Eloit, et al. Transgenic mice expressing a soluble form of porcine nectin-1/herpesvirus entry mediator C as a model for pseudorabies-resistant livestock PNAS, November 16, 2004; 101(46): 16150 - 16155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gotting, S. Muller, M. Schottler, S. Schon, C. Prante, T. Brinkmann, J. Kuhn, and K. Kleesiek Analysis of the DXD Motifs in Human Xylosyltransferase I Required for Enzyme Activity J. Biol. Chem., October 8, 2004; 279(41): 42566 - 42573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jiang, J. B. Wechuck, W. F. Goins, D. M. Krisky, D. Wolfe, M. M. Ataai, and J. C. Glorioso Immobilized Cobalt Affinity Chromatography Provides a Novel, Efficient Method for Herpes Simplex Virus Type 1 Gene Vector Purification J. Virol., September 1, 2004; 78(17): 8994 - 9006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cheshenko, B. Del Rosario, C. Woda, D. Marcellino, L. M. Satlin, and B. C. Herold Herpes simplex virus triggers activation of calcium-signaling pathways J. Cell Biol., October 27, 2003; 163(2): 283 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schelhaas, M. Jansen, I. Haase, and D. Knebel-Morsdorf Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells J. Gen. Virol., September 1, 2003; 84(9): 2473 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gotting, J. Kuhn, H.-R. Tinneberg, T. Brinkmann, and K. Kleesiek High xylosyltransferase activities in human follicular fluid and cultured granulosa-lutein cells Mol. Hum. Reprod., December 1, 2002; 8(12): 1079 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cheshenko and B. C. Herold Glycoprotein B plays a predominant role in mediating herpes simplex virus type 2 attachment and is required for entry and cell-to-cell spread J. Gen. Virol., September 1, 2002; 83(9): 2247 - 2255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Borras, C. R. Brandt, R. Nickells, and R. Ritch Gene Therapy for Glaucoma: Treating a Multifaceted, Chronic Disease Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2513 - 2518. [Full Text] [PDF]
|
|
|
|
|
|
C. J. A. Ring Cytolytic viruses as potential anti-cancer agents J. Gen. Virol., March 1, 2002; 83(3): 491 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nixdorf, B. G. Klupp, and T. C. Mettenleiter Restoration of Function of Carboxy-Terminally Truncated Pseudorabies Virus Glycoprotein B by Point Mutations in the Ectodomain J. Virol., December 1, 2001; 75(23): 11526 - 11533. [Abstract] [Full Text]
|
|
|
|
|
|
F.-Z. Wang, S. M. Akula, N. P. Pramod, L. Zeng, and B. Chandran Human Herpesvirus 8 Envelope Glycoprotein K8.1A Interaction with the Target Cells Involves Heparan Sulfate J. Virol., August 15, 2001; 75(16): 7517 - 7527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mardberg, E. Trybala, J. C. Glorioso, and T. Bergstrom Mutational analysis of the major heparan sulfate-binding domain of herpes simplex virus type 1 glycoprotein C J. Gen. Virol., August 1, 2001; 82(8): 1941 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sakisaka, T. Taniguchi, H. Nakanishi, K. Takahashi, M. Miyahara, W. Ikeda, S. Yokoyama, Y.-F. Peng, K. Yamanishi, and Y. Takai Requirement of Interaction of Nectin-1{alpha}/HveC with Afadin for Efficient Cell-Cell Spread of Herpes Simplex Virus Type 1 J. Virol., May 15, 2001; 75(10): 4734 - 4743. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Schwartz, E. K. Lium, and S. J. Silverstein Herpes Simplex Virus Type 1 Entry Is Inhibited by the Cobalt Chelate Complex CTC-96 J. Virol., May 1, 2001; 75(9): 4117 - 4128. [Abstract] [Full Text]
|
|
|
|
|
|
H. Bultmann, J. S. Busse, and C. R. Brandt Modified FGF4 Signal Peptide Inhibits Entry of Herpes Simplex Virus Type 1 J. Virol., March 15, 2001; 75(6): 2634 - 2645. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Whitbeck, S. A. Connolly, S. H. Willis, W. Hou, C. Krummenacher, M. Ponce de Leon, H. Lou, I. Baribaud, R. J. Eisenberg, and G. H. Cohen Localization of the gD-Binding Region of the Human Herpes Simplex Virus Receptor, HveA J. Virol., January 1, 2001; 75(1): 171 - 180. [Abstract] [Full Text]
|
|
|
|
|
|
D. A. Rauch, N. Rodriguez, and R. J. Roller Mutations in Herpes Simplex Virus Glycoprotein D Distinguish Entry of Free Virus from Cell-Cell Spread J. Virol., December 15, 2000; 74(24): 11437 - 11446. [Abstract] [Full Text]
|
|
|
|
|
|
E. Trybala, J.-A. Liljeqvist, B. Svennerholm, and T. Bergström Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate J. Virol., October 1, 2000; 74(19): 9106 - 9114. [Abstract] [Full Text]
|
|
|
|
|
|
D. B. Anderson, S. Laquerre, W. F. Goins, J. B. Cohen, and J. C. Glorioso Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry J. Virol., March 1, 2000; 74(5): 2481 - 2487. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Whitbeck, M. I. Muggeridge, A. H. Rux, W. Hou, C. Krummenacher, H. Lou, A. van Geelen, R. J. Eisenberg, and G. H. Cohen The Major Neutralizing Antigenic Site on Herpes Simplex Virus Glycoprotein D Overlaps a Receptor-Binding Domain J. Virol., December 1, 1999; 73(12): 9879 - 9890. [Abstract] [Full Text]
|
|
|
|
|
|
C. Krummenacher, A. H. Rux, J. C. Whitbeck, M. Ponce-de-Leon, H. Lou, I. Baribaud, W. Hou, C. Zou, R. J. Geraghty, P. G. Spear, et al. The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC J. Virol., October 1, 1999; 73(10): 8127 - 8137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Hsiao, C.-S. Chung, and W. Chang Vaccinia Virus Envelope D8L Protein Binds to Cell Surface Chondroitin Sulfate and Mediates the Adsorption of Intracellular Mature Virions to Cells J. Virol., October 1, 1999; 73(10): 8750 - 8761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Laquerre, D. B. Anderson, D. B. Stolz, and J. C. Glorioso Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells J. Virol., December 1, 1998; 72(12): 9683 - 9697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Hsiao, C.-S. Chung, and W. Chang Cell Surface Proteoglycans Are Necessary for A27L Protein-Mediated Cell Fusion: Identification of the N-Terminal Region of A27L Protein as the Glycosaminoglycan-Binding Domain J. Virol., October 1, 1998; 72(10): 8374 - 8379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Krummenacher, A. V. Nicola, J. C. Whitbeck, H. Lou, W. Hou, J. D. Lambris, R. J. Geraghty, P. G. Spear, G. H. Cohen, and R. J. Eisenberg Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry J. Virol., September 1, 1998; 72(9): 7064 - 7074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Rux, S. H. Willis, A. V. Nicola, W. Hou, C. Peng, H. Lou, G. H. Cohen, and R. J. Eisenberg Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator J. Virol., September 1, 1998; 72(9): 7091 - 7098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Karger, J. Schmidt, and T. C. Mettenleiter Infectivity of a Pseudorabies Virus Mutant Lacking Attachment Glycoproteins C and D J. Virol., September 1, 1998; 72(9): 7341 - 7348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Terry-Allison, R. I. Montgomery, J. C. Whitbeck, R. Xu, G. H. Cohen, R. J. Eisenberg, and P. G. Spear HveA (Herpesvirus Entry Mediator A), a Coreceptor for Herpes Simplex Virus Entry, also Participates in Virus-Induced Cell Fusion J. Virol., July 1, 1998; 72(7): 5802 - 5810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Peng, M. Ponce de Leon, M. J. Novotny, H. Jiang, J. D. Lambris, G. Dubin, P. G. Spear, G. H. Cohen, and R. J. Eisenberg Structural and Antigenic Analysis of a Truncated Form of the Herpes Simplex Virus Glycoprotein gH-gL Complex J. Virol., July 1, 1998; 72(7): 6092 - 6103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Laquerre, R. Argnani, D. B. Anderson, S. Zucchini, R. Manservigi, and J. C. Glorioso Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread J. Virol., July 1, 1998; 72(7): 6119 - 6130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Laquerre, D. B. Anderson, R. Argnani, and J. C. Glorioso Herpes Simplex Virus Type 1 Glycoprotein B Requires a Cysteine Residue at Position 633 for Folding, Processing, and Incorporation into Mature Infectious Virus Particles J. Virol., June 1, 1998; 72(6): 4940 - 4949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Nicola, M. Ponce de Leon, R. Xu, W. Hou, J. C. Whitbeck, C. Krummenacher, R. I. Montgomery, P. G. Spear, R. J. Eisenberg, and G. H. Cohen Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM J. Virol., May 1, 1998; 72(5): 3595 - 3601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Immergluck, M. Domowicz, N. Schwartz, and B. Herold Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells J. Gen. Virol., March 1, 1998; 79(3): 549 - 559. [Abstract]
|
|
|
|
|
|
K. A. Boyle and T. Compton Receptor-Binding Properties of a Soluble Form of Human Cytomegalovirus Glycoprotein B J. Virol., March 1, 1998; 72(3): 1826 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Roller and D. Rauch Herpesvirus Entry Mediator HVEM Mediates Cell-Cell Spread in BHK(TK-) Cell Clones J. Virol., February 1, 1998; 72(2): 1411 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Feyzi, E. Trybala, T. Bergstrom, U. Lindahl, and D. Spillmann Structural Requirement of Heparan Sulfate for Interaction with Herpes Simplex Virus Type 1 Virions and Isolated Glycoprotein C J. Biol. Chem., October 3, 1997; 272(40): 24850 - 24857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Tran, J. M. Kissner, L. E. Westerman, and A. E. Sears A herpes simplex virus 1 recombinant lacking the glycoprotein G coding sequences is defective in entry through apical surfaces of polarized epithelial cells in culture and in vivo PNAS, February 15, 2000; 97(4): 1818 - 1822. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
