J Gen Virol
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Originally published as JGV in Press, 10.1099/vir.0.010553-0 on April 1, 2009 J Gen Virol 90 (2009), 1962-1966; DOI 10.1099/vir.0.010553-0

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Short Communication

Evaluation of smallpox vaccines using variola neutralization

Inger K. Damon1, Whitni B. Davidson1, Christine M. Hughes1, Victoria A. Olson1, Scott K. Smith1, Robert C. Holman1, Sharon E. Frey2, Frances Newman2, Robert B. Belshe2, Lihan Yan3 and Kevin Karem1

1 Centers for Disease Control and Prevention, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Division of Viral and Rickettsial Diseases, 1600 Clifton Road NE, Atlanta, GA 30333, USA
2 Saint Louis University School of Medicine, Division of Infectious Diseases and Immunology, Edward A. Doisy Research Center, 8th Floor, 1100 S. Grand Blvd, St Louis, MO 63104, USA
3 The EMMES Corporation, 401 N. Washington St, Rockville, MD 20850, USA

Correspondence
Inger K. Damon
iad7{at}cdc.gov

The search for a ‘third’-generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier to acceptance is the absence of challenge models showing induction of correlates of protective immunity against variola virus. In this light, virus neutralization provides one of few experimental methods to show specific ‘in vitro’ activity of vaccines against variola virus. Here, we provide characterization of the ability of a modified vaccinia virus Ankara vaccine to induce variola virus-neutralizing antibodies, and we provide comparison with the neutralization elicited by standard Dryvax vaccination.

A supplementary figure and table are available with the online version of this paper.






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