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Originally published as JGV in Press, 10.1099/vir.0.013201-0 on July 1, 2009 J Gen Virol 90 (2009), 2061-2072; DOI 10.1099/vir.0.013201-0

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Review

Advances in dissecting mosquito innate immune responses to arbovirus infection

Rennos Fragkoudis, Ghassem Attarzadeh-Yazdi, Anthony A. Nash, John K. Fazakerley and Alain Kohl

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Correspondence
Alain Kohl
Alain.Kohl{at}ed.ac.uk

Arthropod-borne viruses – arboviruses – are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In this review, we discuss novel findings in the field of mosquito antiviral responses to arboviruses, in particular RNA interference, the up-and-coming field of general immune-signalling pathways, and cell death/apoptosis.






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