J Gen Virol Try IJSEM Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online ahead of print on 4 March 2009 as doi:10.1099/vir.0.007807-0
Journal of General Virology 2009;90:935.

A more recent version of this article appeared on April 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.007807-0
© 2009 Society for General Microbiology
This Article
Right arrow Full Text (Papers in Press[PDF])
Right arrow All Versions of this Article:
vir.0.007807-0v1
90/4/935    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MARTINEZ-LASO, J.
Right arrow Articles by PICAZO, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MARTINEZ-LASO, J.
Right arrow Articles by PICAZO, J. J.
Agricola
Right arrow Articles by MARTINEZ-LASO, J.
Right arrow Articles by PICAZO, J. J.

Diversity of the G3 genes of human rotaviruses in isolates from Spain from 2004-2006: cross-species transmission and inter-genotype recombination generates alleles

JORGE MARTINEZ-LASO1,3, ANGELA ROMAN1, MIRIAM RODRIGUEZ1, ISABEL CERVERA1, JACQUELINE HEAD2, ICIAR RODRIGUEZ-AVIAL2 and JUAN J. PICAZO2

1 INSTITUTO SALUD CARLOS III;
2 HOSPITAL CLINICO SAN CARLOS

3 E-mail: jmlaso{at}isciii.es

Rotavirus evolves by multiple genetic mechanisms as accumulation of spontaneous point mutations and reassortment events. Other mechanisms such as cross-species transmission and inter-genotype recombination may be also involved. One of the most interesting genotypes in the accumulation of these events is G3. In this work, 6 new G3 Spanish sequences belonging to 0-2 years old patients from Madrid were analysed and compared with 160 others of the same genotype obtained from humans and other host species to establish the G3 genotype evolutionary pathways. The following results were obtained: 1) Four different lineages of the G3 genotype which have evolved in different species were described; 2) Spanish G3 rotavirus sequences are most similar to the sequences described belonging to the lineage I; 3) Several G3 genotype alleles were reassigned as other G genotypes; and 4) Inter-genotype recombination events in G3 viruses involving G1 and G2 were described. These findings strongly suggest multiple inter-species transmission events between different nom-human mammalian species and humans.

Received 9 October 2008; accepted 8 December 2008.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2009 by the Society for General Microbiology.