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Ovine PRNP UTR and promoter haplotype diversity

VLA

¹ E-mail: g.c.saunders{at}vla.defra.gsi.gov.uk

The diversity and possible contribution of non-coding regions of the PRNP gene to TSE susceptibility and PrP protein regulation are not fully known. This study defined ten ovine PRNP promoter and five untranslated region (UTR) haplotypes found in atypical and classical scrapie cases and healthy control sheep. A greater diversity of promoter and UTR haplotypes was observed in linkage with the ARQ PrP allele (7 promoter and 4 UTR haplotypes), whilst other alleles were observed linked with a limited number of haplotypes, such as ARR found to be linked to only two promoter and one UTR haplotype. In silico analysis identified potential transcription factor binding sites (TFBSs) that differed in the promoter haplotype variants. Furthermore, a 5' UTR internal ribosome entry site (IRES) motif was identified in exon 2 and highlights a possible role for this exon in regulating PrP expression at the translational level.

Received 17 October 2008; accepted 22 January 2009.

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				G. C. Saunders, I. Lantier, S. Cawthraw, P. Berthon, S. J. Moore, M. E. Arnold, O. Windl, M. M. Simmons, O. Andreoletti, S. Bellworthy, et al. Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy J. Gen. Virol., October 1, 2009; 90(10): 2569 - 2574. [Abstract] [Full Text] [PDF]