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The complete sequence of a duck astrovirus associated with fatal hepatitis in ducklings

¹ Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine;
² Institute for Animal Health,UK

³ E-mail: zdb{at}cau.edu.cn

Duck astroviruses (DAstVs) are known to cause duck viral hepatitis, however, little is known regarding their molecular biology. Here, we report the complete sequence of a DAstV associated with a recent outbreak of fatal hepatitis in ducklings in China. Sequence analyses indicated that the genome of DAstV possessed a typical astrovirus organization and also exhibited two unique features. The polyadenylated genome comprised 7,722 nucleotides, which is the largest among astroviruses sequenced to date. The open reading frame (ORF) 2 of DAstV was neither in the same reading frame as ORF1a nor as ORF1b, which was distinct from all other astroviruses. Sequence comparisons and phylogenetic analyses revealed that DAstV was more closely related to turkey astrovirus (TAstV) type 2, TAstV-3 and TAstV/MN/01 (a possible new TAstV serotype) than to TAstV-1 or other astroviruses. These findings suggest that astroviruses may transmit across ducks and turkeys.

Received 6 November 2008; accepted 26 January 2009.

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