HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Papers in Press[PDF]) All Versions of this Article: vir.0.008987-0v1 90/5/1256    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ng, T. F. F. Articles by Breitbart, M. Search for Related Content PubMed PubMed Citation Articles by Ng, T. F. F. Articles by Breitbart, M. Agricola Articles by Ng, T. F. F. Articles by Breitbart, M.

Novel anellovirus discovered from a mortality event of captive California sea lions

¹ College of Marine Science, University of South Florida;
² Kansas City Zoo;
³ Marine Mammal Center

⁴ E-mail: mya{at}marine.usf.edu

Viral metagenomics was performed to investigate potential viral pathogens associated with a mortality event of three captive California sea lions (Zalophus californianus). This study identified a novel California sea lion anellovirus (ZcAV), with 35% amino acid identity to feline anelloviruses in the ORF1 region. The double-stranded replicative form of ZcAV was detected in lung tissue, suggesting that ZcAV replicates in sea lion lungs. Specific PCR revealed the presence of ZcAV in the lung tissue of all three sea lions involved in the mortality event, but not in three other sea lions from the same zoo. In addition, ZcAV was detected at low frequency (11%) in the lungs of free-living sea lions. The higher prevalence of ZcAV and presence of the double-stranded replicative form in the lungs of sea lions from the mortality event suggest that ZcAV was associated with the death of these animals.

Received 20 November 2008; accepted 15 January 2009.

This article has been cited by other articles:

				K. Rosario, S. Duffy, and M. Breitbart Diverse circovirus-like genome architectures revealed by environmental metagenomics J. Gen. Virol., October 1, 2009; 90(10): 2418 - 2424. [Abstract] [Full Text] [PDF]