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Published online ahead of print on 25 March 2009 as doi:10.1099/vir.0.009290-0
Journal of General Virology 2009;90:1757.

A more recent version of this article appeared on July 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.009290-0
© 2009 Society for General Microbiology
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Genetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1 CRF07_BC in Xinjiang, China

Ruolei Xin, Xiang He1, Hui Xing, Zhefeng Meng, Yi Feng, Shengya Liu, Jing Wei and Yiming Shao

National Center for AIDS/STD Control and Prevention, China CDC

1 E-mail: xhe{at}chinaaids.cn

To explore the temporal genetic variation of HIV-1 CRF07_BC and reconstruct its epidemic in Xinjiang, China, we studied 216 C2-V4 fragments of env genes sampled from 1996 to 2008. Phylogenetic analysis indicates that the viruses prevailing in Xinjiang form a large monophyletic cluster and may have originated from a common ancestor. The epidemic in Xinjiang was probably established around 1995 (95% confidence interval, 1994-1996). We noted an increased diversity of CRF07_BC over time, with a rapid evolutionary rate we estimated to be 8.3x10-3 substitutions per site per year in the env gene. After 5-6 years of the epidemic (1997-2002), the transmission rate of CRF07_BC in Xinjiang slowed down, although CRF07_BC infection remained at a high prevalence.

Received 3 December 2008; accepted 23 March 2009.




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