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Rev: beyond nuclear export

¹ University of Cambridge;
² University of Warwick

³ E-mail: amll1{at}medschl.cam.ac.uk

Rev remains a hot topic. In this review we revisit the insights that have been gained in the control of gene expression by the retroviral protein Rev and speculate on where current research is leading. We outline what is known about the role of Rev in translation and encapsidation and how these are linked to its more traditional role of nuclear export, underlining the multi-faceted nature of this small viral protein. We discuss what more is to be learnt in these fields and why continuing research on these 116 amino acids and understanding their function is still important in devising methods to combat AIDS, the largest public health problem we face.

Received 3 March 2009; accepted 25 March 2009.

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