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Published online ahead of print on 2 September 2009 as doi:10.1099/vir.0.015727-0
Journal of General Virology 2009;90:2990.

A more recent version of this article appeared on December 1, 2009 J Gen Virol (2009), DOI 10.1099/vir.0.015727-0
© 2009 Society for General Microbiology
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Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

Georg Kochs1,5, Luis Martinez-Sobrido2, Stefan Lienenklaus3, Siegfried Weiss3, Adolfo Garcia-Sastre4 and Peter Staeheli1

1 University of Freiburg;
2 University of Rochester;
3 HZI Braunschweig;
4 Mount Sinai School of Medicine

5 E-mail: georg.kochs{at}uniklinik-freiburg.de

Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated. Here we show that mutants of a highly virulent variant of A/PR/8/34 (H1N1) carrying either a complete deletion or C-terminal truncations of NS1 were far more potent inducers of IFN in infected mice than NS1 mutants derived from standard A/PR/8/34. Efficient induction of IFN correlated with successful initial viral replication in mouse lungs, indicating that the IFN response is boosted by enhanced viral activity. Since the new NS1 mutants can be handled in standard bio-safety laboratories, they represent convenient novel tools for studying virus-induced IFN expression in vivo.

Received 7 August 2009; accepted 28 August 2009.




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