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Cover caption:

Front cover illustration: Generation of a nonsegmented negative-sense RNA virus entirely from cloned cDNA. Cells are cotransfected with protein expression plasmids for polymerase protein, phosphoprotein and nucleoprotein and with a plasmid encoding a full-length viral antigenome. All four transcription units are under the control of the T7 RNA polymerase promoter (yellow triangle). Infection with recombinant vaccinia virus (black oval) provides T7 RNA polymerase, which synthesizes full-length antigenomic viral RNA. Replication and transcription of the viral RNA by the polymerase, phosphoprotein and nucleoprotein yield all necessary viral proteins, resulting in the generation of virus. See the article by G. Neumann, M. A. Whitt and Y. Kawaoka on pages 2635-2662 of this issue. Image courtesy of the authors and Yuko Kawaoka.

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