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Front cover illustration

Three-dimensional reconstruction of human cytomegalovirus by electron cryomicroscopy at 18 Å resolution. The reconstruction is colour-coded according to particle radius, such that the capsid shell is in light-blue, the triplexes and the bulk of the pentons and hexons are in green and the capsid-associated tegument proteins are in yellow. A computationally extracted region containing a triplex and its associated tegument proteins is blown-up and shown on the top. Illustration provided by Z. Hong Zhou at the University of Texas, Houston Medical School, Houston, TX, USA.