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Front cover illustration

Stick-and-ball model of the chemical structure of aciclovir, constructed using the CrystalMaker software for Mac OS X. This image has been created and supplied courtesy of Dr Karl Harrison, Central Chemistry, University of Oxford, UK. See the papers on the characterization of aciclovir-resistant variants of herpes simplex virus by W. Harris and others on pages 1393-1401 and F. Grey and others on pages 1403-1410 of this issue.