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Front cover illustration

HIV-1 docking with the CD4 receptor (green) and chemokine co-receptor (pink) on a CD4⁺ T lymphocyte. Created by Dr Keith Fowke, Viral Immunology Laboratory, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada. See the review article on the mechanisms of CD4⁺ T lymphocyte cell death in human immunodeficiency virus infection and AIDS by J. B. Alimonti and others on pages 1649-1661 of this issue.