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Front cover illustration

Co-localization of Ser-123 mutants of a green fluorescence protein fused to the hepatitis delta virus large antigen (GFP-LD) with SC-35. HeLa cells expressing GFP-LDS123A (top) and GFP-LDS2/123A (bottom) were stained with anti-SC-35 antibody and observed under a fluorescence microscope using the rhodamine channel. The yellow colour shows the co-localization of the GFP fusion protein with SC-35. The green colour indicates the nucleolus or small-sized speckles. Cells that failed to be transfected show their nucleus stained by anti-SC-35 in red. Images courtesy S. J. Lo, Department of Life Science, School of Medicine, Chang Gung University, Taiwan. See the paper by Tan et al. on pp. 1685-1694.