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Front cover illustration

Structure of IBDV-like particle determined by combined electron cryo-microscopy and X-ray crystallography. The electron density map of IBDV-like particles is calculated from electron micrographs using development based on symmetry-adapted function (upper model). Fitting of the atomic model determined by X-ray crystallography (middle model) into the electron microscopy map gives rise to an atomic model of the IBDV-like particle (lower model). Images courtesy Bernard Delmas and Jean Lepault, Laboratoire de Virologie Moléculaire, Gif-sur-Yvette. See the paper by Pous et al., in this issue, pp. 2339-2346.