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Front cover illustration

Influenza virus antigens in the neuronal cytoplasm and axons. Confocal images of cultured neurons from dorsal root ganglia of newborn mice infected with a highly pathogenic avian influenza A virus (strain 24a5b, H5N3) examined at 36 h p.i. Neurons were immunostained for tubulin βIII (green) and nucleus (blue) (upper image), and stained for viral antigen (red) (middle image). The lower image is a merged image of the upper two. Dots of viral antigens among the cell bodies are overlaid on the axons stained for tubulin. Images courtesy Dr Takashi Umemura, Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Japan. See the paper by Matsuda et al. in the April 2005 issue, volume 86, part 4, pp. 1131-1139.