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Front cover illustration

Human metapneumovirus (HMPV) wild-type P protein and an N protein truncation mutant lacking the amino terminus were unable to form or localize to cytoplasmic inclusion-like complexes, even though the N truncation mutant was found to bind to hMPV P by yeast 2-hybrid analysis. LLC-MK2 cells were transfected with GFP-HMPV N7, co-transfected with HMPV P and stained with an anti-HMPV P polyclonal antibody followed by Alexa Fluor 546-labelled (red) secondary antibody. Top, green fluorescence; middle, red fluorescence, bottom, merge. Image courtesy of Dr James E. Crowe, Vanderbilt University School of Medicine, TN, USA. See the paper by Derdowski et al. in this issue, pp. 2698–2708.



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